Photodynamic therapy (PDT) combined with oxygenating strategies is widely employed in cancer treatment; however, oxygen-boosted PDT has failed to achieve an ideal effect due to the complexity, heterogeneity, and irreversible hypoxic environment generated by tumor tissues. With the emergence of Fe-dependent ferroptosis boasting reactive oxygen species (ROS) cytotoxicity as well, such a chemodynamic approach to cancer therapy has drawn extensive attention. In this study, hemoglobin (Hb) is connected with the photosensitizer chlorin e6 (Ce6) to construct a 2-in-1 nanoplatform (SRF@Hb-Ce6) with Sorafenib (SRF, ferroptosis promotor) loaded, combining oxygen-boosted PDT and potent ferroptosis. Benefiting from the intrinsic presence of Fe capable of binding oxygen, hemoglobin concurrently furnishes oxygen for oxygen-dependent PDT and Fe for Fe-dependent ferroptosis. Furthermore, amphiphilic MMP2-responsive peptide is incorporated into the skeleton of the nanoplatform to ensure drug-release specificity for safety improvement. Correlative measurements demonstrate the potentiation of PDT and ferroptosis with SRF@Hb-Ce6. More importantly, PDT strengthens ferroptosis by recruiting immune cells to secrete IFN-γ, which can sensitize the tumor to ferroptosis in our findings. The therapeutic effect of synergistic treatment with SRF@Hb-Ce6 in vitro and in vivo was proven significant, revealing the promising prospects of combined PDT and ferroptosis therapy with the 2-in-1 nanoplatform.

The Fuping Complex is one of the important basement terranes within the central segment of the Trans‐North China Orogen (TNCO) where mafic granulites are exposed as boudins within tonalite–trondhjemite–granodiorite (TTG) gneisses. Garnet in these granulites shows compositional zoning with homogeneous cores formed in the peak metamorphic stage, surrounded by thin rims with an increase in almandine and decrease in grossular contents suggesting retrograde decompression and cooling. Petrological and phase equilibria studies including pseudosection calculation using thermocalc define a clockwise P–T path. The peak mineral assemblages comprise garnet+clinopyroxene+amphibole+quartz+plagioclase+K‐feldspar+ilmenite±orthopyroxene±magnetite, with metamorphic P–T conditions estimated at 8.2–9.2 kbar, 870–882 °C (15FP‐02), 9.6–11.3 kbar, 855–870 °C (15FP‐03) and 9.7–10.5 kbar, 880–900 °C (15FP‐06) respectively. The pseudosections for the subsequent retrograde stages based on relatively higher H2O contents from P/T–M(H2O) diagrams define the retrograde P–T conditions of <6.1 kbar, <795 °C (15FP‐02), 5.6–5.8 kbar, <795 °C (15FP‐03), and <9 kbar, <865 °C (15FP‐06) respectively. Data from LA‐ICP‐MS zircon U–Pb dating show that the mafic dyke protoliths of the granulite were emplaced at c. 2327 Ma. The metamorphic zircon shows two groups of ages at 1.96–1.90 Ga (peak at 1.93–1.92 Ga) and 1.89–1.80 Ga (peak at 1.86–1.83 Ga), consistent with the two metamorphic events widely reported from different segments of the TNCO. The 1.93–1.92 Ga ages are considered to date the peak granulite facies metamorphism, whereas the 1.86–1.83 Ga ages are correlated with the retrograde event. Thus, the collisional assembly of the major crustal blocks in the North China Craton (NCC) might have occurred during 1.93–1.90 Ga, marking the final cratonization of the NCC.

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The Qinling orogenic belt is a complex subduction-accretion-collision orogen that welded the North China Craton and the Yangtze Craton during the final continental collision in the Triassic. The Xiong'ershan area, located in east Qinling, exposes a typical Triassic syenite pluton and several contemporaneous Mo, Au, and Cu deposits. The aegirine-augite syenites and syenites from the Mogou pluton are characterized by alkalic to peralkalic (total alkali Na 2 O + K 2 O = 13.95-14.63 wt.%, CaO = 0.06-2.87 wt.%), and shoshonitic features (K 2 O = 11.86-14.34 wt.%). Zircon LA-ICP-MS U-Pb dating of the aegirine-augite syenite and syenite yield emplacement ages of 232.5 ± 0.6 and 221.8 ± 0.7 Ma, indicating multiple pulses of magmatism. Evidence from zircon Hf isotopes; occurrence of mafic microgranular enclaves; heterogeneous peralkaline composition; and wide ranges of MgO, Ni, and other trace elements suggest that the parental magma was mainly sourced from partial melting of Archean to Paleoproterozoic crustal sources, mixed with juvenile mantle-derived mafic magmas. The Mogou pluton was probably emplaced in the tectonic transition from syn-collision to post-collision settings and accompanying slab break-off process, from the commencement of collision at approximately 245 Ma and post-collisional extension at approximately 210 Ma. Gold, molybdenum, and copper deposits formed during the interval of 255-208 Ma, and the close temporal and spatial relationship between these Triassic polymetallic deposits and the Mogou alkaline pluton invokes a genetic linkage. The heat source for magmatismand related metallogeny is correlated to a hot upwelling asthenospheric mantle that caused partial melting of the Archean to Paleoproterozoic crustal basement, resulting in magma mixing between the two end-members.