The model of vapor condensation heat transfer on downward-facing surfaces with different wettabilities is built by a two-dimensional (2D) lattice Boltzmann method. Dynamic evolution of condensate microdroplets on different wettability surfaces is simulated and the influence on heat transfer performance is analyzed. Moreover, the mechanism of a heterogeneous wettability surface enhancing condensation heat transfer is explored by investigating the condensate behaviors in the process of condensation. The numerical results indicate that as the contact angle of the homogeneous wettability surface increases, the initial nucleation time of the condensate is prolonged, while the departure time of the condensate is reduced significantly. The temperature adjacent to the gas−liquid interface, especially in the three-phase contact line region, is much higher than elsewhere due to the release of latent heat during condensation. Coalescence and detachment behaviors of condensate droplets cause the average heat flux to fluctuate locally with time. For the hybrid wettability surface, if the proportion of hydrophobic regions is small, the condensation heat transfer performance will be deteriorated. However, increasing the hydrophobic−hydrophilic ratio has a positive effect on enhancing heat transfer. It is found that a critical hydrophobic−hydrophilic ratio exists to optimize the heat transfer performance. For the gradient wettability surface, directional migration induced by capillary force facilitates the removal of condensate droplets, thereby enhancing the condensation heat transfer. Furthermore, a larger wetting gradient benefits to further improve the heat transfer performance. The results are valuable for optimally designing the heat transfer enhancement of vapor condensation on functionalized surfaces with heterogeneous wettability.