Our data indicated berberine is a potent suppressor of neuroflammation, presumably through inhibition of NF-κB activation, and suggested berberine has therapeutic potential for the treatment of neuroinflammation that is involved in neurological diseases such as AD.

No abstract

This paper proposes a controller design for the electric pump of a deep-throttling rocket engine. The nonlinearity of the system is taken into consideration by analyzing the gap metric. Then, proportionalintegral-derivative controller and gain-scheduling linear quadratic regulator are designed. Analyzing the amplitude-and phase-frequency characteristics as well as the pole-zero distribution of the system, the results show that the designed controllers can stabilize the linearized equations in incremental form at different operating points. This indicates that these two controllers are available for the original system in the whole range of working conditions and this is verified in the simulation. Meanwhile, the comparison between proportional-integral-derivative controller and gain-scheduling linear quadratic regulator is presented. It demonstrates that the proportional-integral-derivative controller is better at tracking both step and ramp signals but with worse control signals. It means that the proportionalintegral-derivative controller seems less suitable for real use due to severe oscillations. Meanwhile, the parameter tuning of a proportional-integral-derivative controller depends on more extensive manual tuning. Therefore, the gain-scheduling linear quadratic regulator is preferred.

Pseudomonas stutzeri SDM oxidized DL-lactic acid (25.5 g l(-1)) into pyruvic acid (22.6 g l(-1)) over 24 h. Both NAD(+)-independent D-lactate dehydrogenase and NAD(+)-independent L-lactate dehydrogenase were found for the first time in the bioconversion of lactate to pyruvate based on the enzyme activity assay and proteomic analysis.

Our findings suggest that the Rg3 compound of ginseng may be useful for treating patients suffering with Alzheimer's disease.