XBJ can alleviate HS-induced systemic inflammatory response syndrome and liver injury in rats, and improve outcomes. These protective effects may be due to the ability of XBJ to inhibit cytokine secretion by KCs.

The Baidu index would be a useful tool for assessing cyber-user awareness of an emerging infectious disease.

This study was designed to explore whether liver sinusoidal endothelial cells (SECs) play a pathological role in liver injury of heatstroke (HS) in rats. An HS rat model was prepared in a pre-warmed incubator. Rats were randomized into four groups: HS-sham group (SHAM group), the 39°C group, the 42°C group, and the HS group. The serum concentrations of SEC injury biomarkers including hyaluronic acid (HA), von Willebrand factor (vWF), thrombomodulin (TM), were measured. Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and endothelium-derived vasoactive substances including endothelin-1 (ET-1) and nitric oxide (NO) were determined using a commercially available kit. Hepatic tissues were obtained for histopathological examination, electron microscopy examination, immunohistochemistry, and reverse transcription polymerase chain reaction (PCR) analysis. Our study team found increased levels of plasma ALT/AST during the course of HS. We were also able to detect microcirculation changes and inflammatory injury of the liver (especially in the sinusoidal areas). In addition, markers of SEC injury were significantly elevated. Thrombosis-related markers including vWF and TF expression levels were significantly upregulated and TM levels downregulated. Furthermore, imbalance between ET-1 and NO levels were detected. In conclusion, damage of SECs could result in microcirculation disturbances and pro-inflammatory injury in the liver during HS, which could prove to be a potential pathogenic mechanism of liver injury in HS.

Nowadays, there is a great deal of interest in the development of practical optimization models and intelligent solution algorithms for solving disassembly-line balancing problems. Based on the importance of energy efficiency of product disassembly and the trend for green remanufacturing, this paper develops a new optimization model for the energy-efficient disassembly-line balancing problem where the goal is to minimize the energy consumption generated during the disassembly-line operations. Since the proposed model is a complex optimization problem known as NP-hard, this study develops an improved metaheuristic algorithm based on the water cycle algorithm as a recently developed successful metaheuristic inspired by the natural water cycle phenomena of diversion, rainfall, confluence, and infiltration operations. A local search operator is added to the main algorithm to improve its performance. The proposed algorithm is validated by the exact solver and compared with other state-of-the-art and recent metaheuristic algorithms. A case study in a turbine reducer with different parameters is solved to show the applicability of this paper. Finally, our results confirm the high performance of the proposed improved water cycle algorithm and the efficiency of our sensitivity analyses during some sensitivity analyses.