ADAM17 (a disintegrin and metalloproteinase 17) is overexpressed in many types of cancer, and its high expression in cancer patients is associated with increased risk of metastasis and a poorer prognosis. However, the clinical value of ADAM17 as a tumor biomarker remains largely unknown. In this meta-analysis, we investigated the relationships between ADAM17 levels, cancer metastasis, and patient prognosis. Twelve eligible studies involving a total of 1816 patients were identified in searches of the PubMed, Embase, Cochrane, and Chinese National Knowledge Infrastructure databases. Analysis of these studies revealed that ADAM17 overexpression is positively associated with lymph node metastasis in a fixed effect model and distant metastasis in a random effect model. Moreover, high ADAM17 expression was predictive of shorter overall and progression-free survivalof cancer patients in fixed effect models. These results suggest that ADAM17 maybe a useful biomarker for predicting metastasis and prognosis in cancer patients and may also aid in risk stratification and selection of individualized treatments.

Lysozyme was subjected to coacervate with carboxymethyl konjac glucomannan (CMKGM) to check if dispersible coacervates could be formed to extend its application in edible coatings. The results indicated that complex coacervation could occur between lysozyme and CMKGM only within a narrow pH range from pH 2.5 to 6.0 and the maximum interaction was recorded in a moderate temperature of 35 °C in the absence of NaCl. The dispersion status of the lysozyme – CMKGM coacervates was closely related to the phase separation pH as well as lysozyme to CMKGM mixing ratio and conditions that led to the presence of free CMKGM in the solution favored the formation of dispersible coacervates. Rheological measurements revealed the high viscosity of CMKGM solution contributed greatly to the dispersion status of the lysozyme – CMKGM coacervates. Coacervation with CMKGM caused structural changes to lysozyme, but only slightly affected its lytic activity. Contact angle measurement revealed that the lysozyme – CMKGM coacervates were more hydrophobic than the two single polyelectrolytes. Hence, the dispersible lysozyme – CMKGM coacervates were potential in the fabrication of composite antibacterial edible coatings.

Low temperature plasma (LTP) is a developing eld in recent years to play important roles of sterilization, material modi cation and wound healing. Breast cancer is a common gynecological malignant tumor. Recent studies have shown that LTP is a promising selective anti-cancer treatment, because some cancer cells are highly sensitive to reactive oxygen species (ROS) produced by LTP, but non-tumor cells are highly resistant to it, which indicates that the main effect of LTP is mediated through the generation of ROS. The effect of LTP on breast cancer is still unclear. In this study, We treated breast cancer cell lines with low temperature plasma for different periods of time and analyzed the relevant differences. we found that LTP was able to suppress cell vitality, proliferation, invasion and migration of SK-BR-3 cells. Also, SK-BR-3 apoptosis was induced by LTP in a time-dependent manner. These evidences suggest the negative effect of LTP on malignant development of SK-BR-3 cells, and LTP has the potential clinical application for breast cancer treatment. BackgroundLow temperature plasma (LTP) is an ionized gaseous substance composed of positive and negative ions produced by atoms and atomic groups after partial electron deprivation. It is often regarded as the fourth substance state 1, 2 . LTP physics provides new technologies for materials, energy, environmental space, biomedicine and other elds 2 . At present, LTP application in biomedical elds such as sterilization, material surface modi cation, dentistry, skin treatment, wound healing and tumor treatment, is increasing [3][4][5][6][7][8][9] . Due to the characteristic of no side effects 10 , LTP has become a new research hotspot in the biomedicine eld. Previous studies have reported that LTP is bene cial for surgery and disease treatment, especially tumor treatment [11][12][13] , which effectively induces tumor cell apoptosis, including liver cancer 14,15 , colorectal cancer 16 , lung cancer 17, 18 and pancreatic cancer 19,20 . With the different intracellular metabolism levels and ROS production 21,22 , while killing tumor cells, LTP barely shows cytotoxicity to normal cells and tissues 23 . Therefore, as an emerging technology, LTP has a very promising prospect in cancer treatment.The causes and progress of breast cancer are very complex, and the current research suggests that breast cancer development is a multi-stage process. There are many risk factors for breast cancer occurrence and development, including hormone effects, genetic factors, radiation and mental disorders 24,25 . Multiple signaling pathways have been reported to be closely associated with breast cancer progress, like p53 26 , p38 MAPK 27, 28 and NF-κB 29 . Generally, the main clinical therapy for breast cancer is based on surgery and radiotherapy accompanying by chemotherapy. However, radiotherapy and chemotherapy have strong side effects 30 , and searching for other treatments with less even no side effect is very important.Considering the extended application of LTP in various biomedi...

No abstract