No abstract

Facilitated by the supramolecular synthons of carboxylic acids and amides through cooperative hydrogen‐bonding and arene–perfluoroarene interactions, the azide–alkyne cycloaddition reaction between two different molecules in a cocrystal was achieved. This reaction could be accelerated by pressure using a common hydraulic press equipment with excellent regioselectivity to yield 1,4‐triazole products. The absence of decarboxylation side reactions in the products in the solid state demonstrated that this strategy can provide a green synthetic route for products not directly accessible by traditional syntheses in solution.

Visible mechanochromism was triggered via the ring-opening reaction of phenolphthalein under high pressure. Different ring-opening threshold pressures and responsive colors were achieved by changing the substituent groups with different electronic effects.