Various aryl triflates, bearing ketone or aldehyde groups, were evaluated for palladium-mediated introduction of an amino group at the triflate position in the presence of various phosphine ligands. BINAP was best for secondary amines, MOP-type ligand for primary or small secondary amines and Xantphos for primary or cyclic secondary amides. No ligand was found effective for acyclic secondary amides.

Amination O 0268Palladium-Catalyzed Substitution of Ketone or Aldehyde Bearing Aryl Triflates by Amines or Amides. -Various aryl triflates (I) and (IV), bearing ketone or aldehyde groups, are evaluated for Pd-mediated introduction of an amino group at the triflate position in the presence of various phosphine ligands. -(TAO*, X.; DAI, C.; CAO, X.; CAI, L.; PIKE, V. W.; Chin.