Poly(methylacrylamide) (PMAM) is a thermo-responsive polymer with an upper critical solution temperature (UCST). Its cloud point (T cp ) is around 60 C, unsuitable for certain biomedical and industrial applications. This study brought up a copolymerization strategy to tune the T cp of PMAM with hydrophilic comonomers. Surprisingly, with a small portion of hydrophilic monomer doped, the T cp of the PMAM copolymer can be significantly shifted. For instances, with ≤7 mol% of acrylamide or 1 mol% of oligo(ethylene glycol) methacrylate, the T cp can be shifted in a wide range from~69 to~0 C. Microdifferential scanning calorimetry demonstrated that the enthalpic effect during the phase transition of the solutions is indistinctive, while fluorescence measurement with pyrene as a probe revealed that the hydrogen-bonding within polymer chains is enhanced by the hydrophobic aggregation of methyl groups.Therefore, the doped hydrophilic monomer could remarkably alter the ordering of water-molecules and the extent for the aggregation of methyl groups, leading to the pronounced shifting in the T cp of the copolymers. This work would facilitate the application of PMAM as smart polymer materials and guide the inventions of functional materials based on UCST polymers.

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