In order to improve the operation efficiency of the innovation and entrepreneurship integration system of college students, this document proposes to formulate and implement the innovation and entrepreneurship integration system of college students based on “Internet technology.” The web front end is implemented by Django technology, the back end is developed by Apache server pycharm, the database is written in Python, and the database is MySQL. The system meets the expected objectives of implementing, monitoring, and managing innovation and entrepreneurship projects. How the system realizes the functions of repeated comparison projects, easy tracking projects, and fast search, and how managers can make progress at any time. By creating different account function permissions, the system realizes the login, declaration, management, and other functions required by the users of the innovation and entrepreneurship project management system. It is very suitable for college students to improve the project application, information review, and application process. At the same time, it is helpful to supervise and select teachers and greatly improve management efficiency. The test results show that the minimum values of 30, 80, and 150 simulated users in the system performance test are 4, 5, and 7, respectively. The maximum users of the system performance test model are 30, 80, 150, 64, 284, and 398. The system performance tests are taken under the conditions of 30, 80, and 150 user bandwidth, with the results of 113/min, 104/min, and 90/min. The system basically meets the daily work management standards and fully achieves the expected system design goals. The development and use of this system are related to the development of college students’ innovation and entrepreneurship project management and have a clear reference for the development of innovation and entrepreneurship project management systems similar to manage workflow in the future.