In this work, through integrate that teaching management system, the learn mode of the O2O is used to build a learner‐centered frame of the teaching reformation. This frame is supported by the O2O learning platform, with themed practical teaching and O2O model as the main body, and the “Thousand questions plan” and “Teachers guiding” system as two guarantee supports. In order to achieve high quality results, specific implementation plan, including management system and implementation measures has been formulated in teaching reform of O2O platform. The questionnaire shows that this system has mobilized the enthusiasm of teachers and students. By comparing the practice results of the experimental class and the control class, the effectiveness of the O2O teaching framework is verified, and the teaching reform is successful. Finally, this paper provides teaching inspiration and future research direction for educators and researchers.

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