Preoperative NLR and PLR were found to be correlated to unfavorable histopathologic features of cervical cancer. The preoperative NLR, but not PLR, may be used as a potential and easy biomarker for survival prognosis in patients with cervical cancer receiving initial radical hysterectomy with pelvic lymphadenectomy.
The
development of multifunctional nanoscale radiosensitizers has
attracted a tremendous amount of attention, which can enhance the
radiosensitization of tumor tissues and reduce unnecessary damage
to the surrounding organs. However, the persistent hypoxia environment
within the tumor limits their applications in radiotherapy. In this
paper, a stable nanocomposite was engineered to overcome the hypoxia
properties by using 1,4-benzenedicarboxylic acid produced from a Zr-MOF
as a carbonic anhydrase IX (CA IX) inhibitor and quercetin (QU) as
a radiosensitizer. QU was encapsulated into the Zr-MOF structure to
achieve a synergetic dual sensitization therapy. Zr-MOF-QU exhibits
an excellent potential of radiotherapy sensitization characteristics in vitro and in vivo from the γ-H2AX immunofluorescence staining and colony assays. The mechanisms
of alleviating hypoxia-induced resistance and sensitizing tumor tissues
to improve cell apoptosis from radiation were found to suppress CA
IX expressions by the decomposition product from Zr-MOF and boost
the sensitivity by QU in radiation therapy. Moreover, there was no
significant systemic toxicity during the treatment, and the therapeutic
outcome was assessed in animal models. Therefore, our results demonstrate
a promising cancer treatment approach in the radiation field.
LAPTM4B over-expression is an independent factor in stages III-IV epithelial ovarian carcinoma prognosis and chemotherapy resistance, and it may be an important potential biomarker.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.