A new multi-modal therapies agent FePt/BP-PEI-FA nanoplatform, loaded FePt nanoparticles (FePt NPs) onto ultrathin Black phosphorus nanosheets (BPNs), has been constructed to enhance synergistic Photothermal therapy (PTT), Photodynamic therapy (PDT),...

As a multifunctional platform for photo-chemo-immunotherapy strategies, FePt/MoS2 nanocomposites shows great potential in cancer theranostic.

Reactive oxygen species (ROS)-based anticancer therapy methods were heavily dependent on specific tumor microenvironments such as acidity and excess hydrogen peroxide (H 2 O 2 ). In this work, an acidity-sensitive nanotheranostic agent (FePt@MnO)@DSPE-PEG5000-FA (FMDF NPs) was successfully constructed for MR imaging guided ferroptosis chemodynamic therapy (FCDT) of cancer. The FMDF NPs could specifically target folic acid (FA) receptor-positive tumor cells (HeLa etc.) and induce ferroptosis efficiently by rapidly releasing active Fe 2+ to catalyze intracellular H 2 O 2 into ROS based on Fenton reaction. On the other hand, the Mn 2+ could also be released due to acidity and further coordinate with GSH to enhance the longitudinal-transverse relaxivity (T 1 /T 2 -weighted MR imaging), which could obviously strengthen the contrast distinction between solid tumors and the surrounding tissue to accurately real-time monitor the tumor location. Furthermore, the in vivo anticancer study revealed that the growth of solid tumor models could be suppressed remarkably after treating with FMDF NPs and no obvious damage to other major organs. Therefore, the FMDF NPs were competent simultaneously as an enhanced imaging diagnosis contrast agent and efficient therapy agent for promoting more precise and effective treatment in the bionanomedicine field.