Doxorubicin (DOX) is an important anticancer drug used widely in the treatment of leukemia and lymphoma. The suitability of DOX is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. This study is designed to determine the effect of Phoenix dactylifera extract (PDE) on DOX-induced cardiotoxicity and nephrotoxicity. Experimental rats were divided into four groups, receiving normal saline 4 ml/kg, DOX alone, and crude extract of PDE at doses of 1 g/kg and 1.5 g/kg in the presence of DOX, respectively, for 21 days. Cardiac enzymes and serum and urinary sodium and potassium levels were evaluated which were analyzed statistically by using one-way ANOVA. Subsequently, DOX initiated changes in the level of cardiac markers CK-MB, LDH, and troponin I, which were notably reversed by PDE. PDE was also effective against serum and urinary sodium and urinary potassium and protected against DOX-induced nephrotoxicity. Groups treated with different doses of PDE showed marked decrease in levels of cardiac and renal markers. The study concluded that the PDE extract possesses protective effects against DOX-induced cardiotoxicity and nephrotoxicity.

AR/VR technology can fuse the clinical imaging data and information to build an anatomical environment combining virtual and real, which is helpful to improve the interest of teaching and the learning initiative of medical students, and then improve the effect of clinical teaching. This paper studies the application and learning effect of the VR/AR system in human anatomy surgery teaching. This paper first shows the learning environment and platform of the VR/AR system, then explains the interface and operation of the system, and evaluates the teaching situation. This paper takes the VR/AR operation simulation system of an Irish company as an example and evaluates the learning effect of 41 students in our hospital. Research shows that the introduction of the feature reweighting module in the VR/AR surgery simulation system improves the accuracy of bone structure segmentation (IOU value increases from 79.62% to 83.56%). For real human ultrasound image data, the IOU value increases from 80.21% to 82.23% after the feature reweighting module is introduced. Therefore, the dense convolution module and feature reweighting module improve the learning ability of the network for bone structure features in ultrasound images from two aspects of feature connection and importance understanding and effectively improve the performance of bone structure segmentation.

Oxidative stress are involved in the pathogenesis of acute lung injury (ALI). Accordingly, anti-inflammatory treatment is proposed to be a possible efficient therapeutic strategy for ALI. The aim of the study was to evaluate the antioxidant efficacy of Artesunate (Ar) on ALI induced by lipopolysaccharide (LPS) in mice and explore the underlying mechanism. BALB/c mice received Ar (2, 4 mg/kg) intraperitoneally 1h prior to the in intratracheal instillation of lipopolysaccharide (LPS) challenge. Malondialdehyde (MDA) was detected to evaluate the anti-oxidant efficacy of Artesunate.Content of Superoxide Dismutase (SOD) and Catalase (CAT) were assayed by enzyme linked immunosorbent assay (ELISA).Western blot was employed to determine the protein expression of P-PI3K,PI3K, P-AKT and AKT. The results showed the severity of lung injury was attenuated by Ar (40 mg/kg) and Dex (2 mg/kg) and the levels of MDA in Ar (20, 40 mg/kg) and Dex (2mg/kg) groups were obviously lower than those in LPS group. The treatment with Ar (20, 40 mg/kg) and Dex (2 mg/kg) remarkably increased the levels of SOD and CAT. The protein expressions of signaling showed the protein expressions of PI3Kand ATK significantly enhanced compared with those in LPS group after Areating with Ar (20 and 40 mg/kg) and Dex (2 mg/kg). In conclusion, this study revealed that Artesunate could exert protective effect of on LPS-induced acute lung injury by anti-oxidant through AKT/PI3K pathway.