The precise modification of redoxs pecies on the inner and outer surfaces of hollownanostructures is relevant in catalysis,surface science,and nanotechnology,but has proven difficult to achieve.H erein, we develop af acile approach to specifically fabricate Pt and Co 3 O 4 nanoparticles (NPs) onto the interior and exterior surface of hollowc arbon nitride spheres (HCNS), respectively,t op romote the surface redox functions of the polymer semiconductors.T he photocatalytic water splitting activities of HCNS with spatially separated oxidation and reduction centers at their nanodomains were enhanced. The origin of the enhanced activity was attributed to the spatially separated reactive sites for the evolution of H 2 and O 2 and also to the unidirectional migration of the electron and hole on the Janus surfaces,t hereby preventing the unwanted reverse reaction of water splitting and decreasing charge recombination.

Carbon-based catalysts have demonstrated great potential for the aerobic oxidative dehydrogenation reaction (ODH). However, its widespread application is retarded by the unavoidable deactivation owing to the appearance of coking or combustion under ODH conditions. The synthesis and characterization of porous structure of BCN nanosheets as well as their application as a novel catalyst for ODH is reported. Such BCN nanosheets consist of hybridized, randomly distributed domains of h-BN and C phases, where C, B, and N were confirmed to covalent bond in the graphene-like layers. Our studies reveal that BCN exhibits both high activity and selectivity in oxidative dehydrogenation of ethylbenzene to styrene, as well as excellent oxidation resistance. The discovery of such a simple chemical process to synthesize highly active BCN allows the possibility of carbocatalysis to be explored.

The precise modification of redoxs pecies on the inner and outer surfaces of hollownanostructures is relevant in catalysis,surface science,and nanotechnology,but has proven difficult to achieve.H erein, we develop af acile approach to specifically fabricate Pt and Co 3 O 4 nanoparticles (NPs) onto the interior and exterior surface of hollowc arbon nitride spheres (HCNS), respectively,t op romote the surface redox functions of the polymer semiconductors.T he photocatalytic water splitting activities of HCNS with spatially separated oxidation and reduction centers at their nanodomains were enhanced. The origin of the enhanced activity was attributed to the spatially separated reactive sites for the evolution of H 2 and O 2 and also to the unidirectional migration of the electron and hole on the Janus surfaces,t hereby preventing the unwanted reverse reaction of water splitting and decreasing charge recombination.

Se-modified carbon nitride nanosheets with fluorescent properties and high biocompatibility show efficient free radical cleaning activity, and can be used as biomimetic catalases for resisting oxidative stress.

Dual-targeted nanoparticles are gaining increasing importance as a more effective anticancer strategy by attacking double key sites of tumor cells, especially in chemophotodynamic therapy. To retain the nuclei inhibition effect and enhance doxorubicin (DOX)-induced apoptosis by mitochondrial pathways simultaneously, we synthesized the novel nanocarrier (HKH) based on hollow carbon nitride nanosphere (HCNS) modified with hyaluronic acid (HA) and the mitochondrial localizing peptide D[KLAKLAK]2 (KLA). DOX-loaded HKH nanoparticles (HKHDs) showed satisfactory drug-loading efficiency, excellent solubility, and very low hemolytic effect. HA/CD44 binding and electrostatic attraction between positively charged KLA and A549 cells facilitated HKHD uptake via the endocytosis mechanism. Acidic microenvironment, hyaluronidase, and KLA targeting together facilitate doxorubicin toward the mitochondria and nuclei, resulting in apoptosis, DNA intercalation, cell-cycle arrest at the S phase, and light-induced reactive oxygen species production. Intravascular HKHD inhibited tumor growth in A549-implanted mice with good safety. The present study, for the first time, systemically reveals biostability, targetability, chemophotodynamics, and safety of the functionalized novel HKHD.