PurposeThe purpose of this paper is to investigate the associations among knowledge-oriented leadership (KOL), knowledge worker satisfaction (KWS), knowledge worker productivity (KWP) and organizational performance (OP). The study hypothesizes that the explicit mixtures, i.e. KOL, KWS and KWP can improve OP.Design/methodology/approachThe study sample was composed of 248 academicians and management staff of higher educational institutes (HEIs). The relations were tested through Smart PLS 3.2.9. The fuzzy-set qualitative comparative analysis (fsQCA) method was also used for examining configurational paths.FindingsThe study found a substantial direct influence of KOL on OP. The findings revealed that KOL significantly affects KWS, and KWS enhances KWP, which ultimately improves the OP of HEIs. Grounded on the fsQCA, the outcomes exposed configurational trails to the enhanced OP.Originality/valueThere is scarce of studies that determine the connection of KOL, KWS, KWP and OP. This is one of the preliminary studies that examine the association of KOL, KWS, KWP and OP in HEIs. From a procedural viewpoint, the research subsidizes by merging symmetric and asymmetric tools to further understand structural issues. The use of fsQCA discloses numerous paths to improve OP and renders asymmetric relations. fsQCA also aids to comprehend the relations that might not be directly understandable via symmetric means.

Background Mutations in transcription factor NKX2.5 cause congenital heart disease (CHD). We identified a CHD family with atrial septal defects (ASDs), atrioventricular block, ventricular noncompaction, syncope and sudden death. Our objective is to identify the disease-causing mutation in the CHD family. Methods Direct DNA sequence analysis was used to identify the CHD mutation. The functional effects of the mutation were characterized by a luciferase reporter assay and immunostaining. Results A novel, de novo 2-bp insertion (c.512insGC) was identified in exon 2 of NKX2.5. Mutation c.512insGC co-segregates with CHD in the family, and is not present in 200 controls. Functional studies indicate that the c.512insGC mutation impedes nuclear localization of NKX2.5 and causes a total loss of transactivation activity of NKX2.5. Furthermore, no NKX2.5 mutation was identified in 125 sporadic Chinese CHD patients. Conclusions (1) NKX2.5 mutation c.512insGC is associated with ASDs, syncope and sudden death. It is the second de novo mutation identified in NKX2.5. (2) NKX2.5 mutations are rare in sporadic CHD patients. (3) This study for the first time identifies association between a NKX2.5 mutation and ventricular noncompaction. Our results significantly expand the phenotypic spectrum of NKX2.5 mutations.

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PurposeThis research examines how knowledge management (KM) enablers, i.e. trust, knowledge-oriented leadership, environmental uncertainty and KM processes will impact knowledge worker productivity (KWP). Various formations of the KM enablers and KM processes are also examined within terms of their abilities to enhance KWP.Design/methodology/approachThe research sample is taken from 248 faculty and administrators of Pakistan Higher Educational Institutes (HEIs). The relationships are tested via SmartPLS and fsQCA 3.0.FindingsThe results show that there are significant impacts of the KM enablers on KM processes and KWP. Constructed upon fuzzy qualitative comparative analysis (fsQCA), the outcomes exposed various combinations, which can be identified to enhance KWP.Originality/valueThe research supports to methodology by merging two methods to advance the understanding of institutional concerns about workers' productivity. The asymmetric method assists to distinguish the connections that might not be directly clear via traditional symmetric approaches. By uncovering asymmetric relationships, the study identifies a variety of approaches that can be used by HEIs to improve their KWP.

Understanding the psychiatric symptoms of COVID-19 could facilitate the clinical management of COVID-19 patients. However, the profile of psychiatric symptoms among COVID-19 patients has been understudied. We performed a meta-analysis of studies assessing psychiatric symptoms of COVID-19 and SARS patients and survivors by using the Symptom Checklist-90-Revised (SCL-90-R), an instrument covering a wide spectrum of psychiatric symptoms. Studies reporting SCL-90-R subscale scores among patients with and survivors of COVID-19 and SARS were retrieved from major English and Chinese literature databases. Patients’ pooled SCL-90-R subscale scores were compared to the Chinese normative SCL-90-R data, and Cohen’s d values were calculated to indicate the severity of psychiatric symptoms. The Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data was used to assess the quality of the included studies. The search yielded 25 Chinese studies with 1675 acute COVID-19 and 964 acute SARS patients, 30 COVID-19 and 552 SARS survivors during very early recovery (up to 1 month since discharge), 291 SARS survivors during early recovery (1–6 months after discharge), and 48 SARS survivors during late recovery (12 months after discharge). None of the included studies were rated as good quality. The ten SCL-90-R-defined psychiatric symptoms, which were of medium-to-severe severity (d = 0.68–3.01), were all exhibited in acute COVID-19 patients, and the severity of these symptoms decreased to mild-to-medium during very early recovery (d = 0.17–0.73). SARS patients presented eight psychiatric symptoms with mild-to-severe severity during the acute stage (d =0.43–1.88), and thereafter, the severity of symptoms decreased over the follow-up period. However, somatization (d = 0.30) and anxiety (d = 0.28) remained at mild levels during late recovery. A wide variety of severe psychiatric symptoms have been reported by acute COVID-19 patients, and these symptoms, despite decreasing in severity, persist in very early recovery. The changing trajectory observed with SARS suggests that psychiatric symptoms of COVID-19 may persist for a long time after discharge, and therefore, periodic monitoring of psychiatric symptoms, psychosocial support, and psychiatric treatment (when necessary) may be necessary for COVID-19 patients from the acute to convalescent stages.