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Based on Lejeune Dirichlet allocation (LDA) model and multi-relationship topic model in Diagnosis and treatment of traditional Chinese medicine (TCM), the Symptom TCMTreatment Diagnosis (STTD) model is purposedto extract topic structure of symptom, TCM, treatment and diagnosis from TCM clinical datum.This paper uses Gibbs sampling to do parameters reasoning and confirms the optimalnumber of topicsaccording to the average similarity amongtopics. From the experimental results, given the symptoms of patient, STTD model can predicts treatment, result of diagnosis, TCM and the distribution of topic. And it is available for clinical doctors and researchers.