A fluoride-promoted
intramolecular Sakurai allylation of geminal
bis(silyl) enamide with indolenine has been developed. The reaction
facilitates an efficient cyclization to give hexahydropyrido[3,4-b]indoles in good yields with high diastereoselectivity.
The resulted cis, trans-stereochemistry
further enables the ring-closing metathesis (RCM) reaction of two
alkene moieties, giving a tetracyclic N-hetereocycle
widely found as the core structure in akuammiline alkaloids.
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