Background: Angina pectoris is a kind of cardiovascular disease, which is caused by epicardial stenosis, microvascular dysfunction, dynamic stenosis area contraction or more comprehensive factors, eventually leading to Coronary artery disease. Rhodiola wallichiana var. cholaensis, which is one of the most well-known Traditional Chinese Medicine, is widely used to treat angina pectoris. However, the possible underlying mechanisms remain to be elucidated.Methods: In this study, systematic and comprehensive network pharmacology and molecular docking were utilized for the first time to reveal the potential pharmacological mechanisms of RW on AP. Firstly, the relative compounds were obtained by mining literature and potential targets of these compounds by target predicting were collected. Then, We built the AP target database using the DigSee and GeneCards Database. Based on the data, GO and KEGG pathway enrichment analysis, protein-protein interaction (PPI) analysis were performed and screen the hub targets by topology. Furthermore, evaluation of the binding potential of key targets and compounds through molecular docking.Results: The results indicate that 218 known RW therapeutic targets were selected. By systematic analysis, identified 9 hub targets (VEGFA, GAPDH, TP53, AKT1, CASP3, STAT3, TNF, MAPK1 and JUN) mainly involved in the complex treating effects associated with the protection of vascular endothelium, as well as the regulation of glucose metabolism, cellular processes, inflammatory responses, and cellular signal transduction.Conclusion: The results of this study preliminarily explain the potential targets and signaling pathways of RW in AP therapy and lay a good foundation for further experimental studies and clinical trials.