A copper-catalyzed Markovnikov-type intermolecular azidocyanation of aryl alkenes has been developed to give a series of α-azido-propanenitriles in moderate to good yields. This method may provide a potential strategy for the synthesis of corresponding 3-amino-2-arylpropanoic acid.

In the present paper, the Cu(I)-catalyzed intramolecular aminotrifluoromethylation of O-homoallyl benzimidates with Togni reagent I was reported. O-Homoallyl benzimidates equipped with terminal alkenes produced chiral 1,3-oxazines with high enantioselectivity in the presence of a chiral BOX ligand, and racemic tetrahydro-1,3-oxazepines were obtained in high yields from internal alkene derivatives with a monoprotected amino acid additive under similar conditions.

A Zn(OTf)-promoted cyclization reaction of tosylhydrazones with 2-(dimethylamino)malononitrile has been successfully developed providing an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles.

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