Osteoporosis is one of the most common bone disorders that seriously affect the health and life quality of elderly individuals. Reduced osteoblast differentiation and bone formation lead to changes in...

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Covariance analysis describing function technique is a conventional method to solve the performance analysis of the nonlinear missile guidance system. Aiming at the faultiness of covariance analysis describing function technique and its improved method, this paper proposes a new method to solve the mean and covariance transfer issue by using the high-degree spherical-radial cubature rule. In terms of simulation models, the nonlinear missile guidance system contains the saturation link to limit the lateral acceleration command and the initial heading error is introduced. In addition, the zero-mean target evasive maneuver with exponentially-decaying autocorrelation function is chosen as the input of the missile guidance system. Furthermore, compared with the existing methods, the proposed method has higher computational efficiency, accuracy and better applicability in high-dimensional nonlinear systems by theoretical derivation and simulation results from the mean and covariance values of relative lateral separation. Finally, the presented analysis method can be used as a general method for the design and statistical analysis of multidimensional nonlinear systems.

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Bone loss induced by microgravity exposure seriously endangers the astronauts’ health, but its countermeasures still have certain limitations. The study aims to find potential protective drugs for the prevention of the microgravity-induced bone loss. Here, we utilized the network pharmacology approach to discover a natural compound calycosin by constructing the compound-target interaction network and analyzing the topological characteristics of the network. Furthermore, the hind limb unloading (HLU) rats’ model was conducted to investigate the potential effects of calycosin in the prevention of bone loss induced by microgravity. The results indicated that calycosin treatment group significantly increased the bone mineral density (BMD), ameliorated the microstructure of femoral trabecular bone, the thickness of cortical bone and the biomechanical properties of the bone in rats, compared that in the HLU group. The analysis of bone turnover markers in serum showed that both the bone formation markers and bone resorption markers decreased after calycosin treatment. Moreover, we found that bone remodeling-related cytokines in serum including IFN-γ, IL-6, IL-8, IL-12, IL-4, IL-10 and TNF-α were partly recovered after calycosin treatment compared with HLU group. In conclusion, calycosin partly recovered hind limb unloading-induced bone loss through the regulation of bone remodeling. These results provided the evidence that calycosin might play an important role in maintaining bone mass in HLU rats, indicating its promising application in the treatment of bone loss induced by microgravity.