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The authors declare no competing financial interests. Data availability HTGTS V(D)J-seq, Hi-C, 3C-HTGTS, GRO-Seq and ChIP-Seq sequencing data reported in this study has been deposited in the GEO database under the accession number GSE130224. Specifically, HTGTS V(D)J-seq data is deposited in the GEO database under the accession number GSE130216 and is related to Fig. 1e-h; 2b, c; 3a-c, e; 4c; Extended Data Fig. 2c-e, g, h; 3e, f; 4a, c, d; 5a-c; 6c; 7d, e; 9b; and Supplementary Information Table 1&2. Hi-C data is deposited in the GEO database under accession number GSE134543 and is related to Extended Data Fig. 8a. 3C-HTGTS data is deposited in the GEO database under the accession number GSE130214 and is related to Fig. 3f; 4d; and Extended Data Fig. 8a; 9c; 10q, r. GRO-Seq data is deposited in the GEO database under the accession number GSE130215 and is related to Fig. 3d; 4b; and Extended Data Fig. 4e; 6d; 7f; 9b. ChIP-Seq data is deposited in the GEO database under the accession number GSE130213 and is related to Extended Data Fig. 8c, d; 9d. Code availability. HTGTS V(D)J-seq and 3C-HTGTS data was processed through published pipeline available at (http://robinmeyers.github.io/ transloc_pipeline/). Code for Hi-C data process is available at (github.com/aidenlab). GRO-Seq and ChIP-Seq were aligned to mm9 genome with bowtie2 v2.2.8 (http://bowtie-bio.sourceforge.net/bowtie2/index.shtml), processed by samtools v1.8 (https:// sourceforge.net/projects/samtools/files/samtools/1.8/) and generated graph files via RSeQC tool v2.6 (http://rseqc.sourceforge.net/ #bam2wig-py).