No abstract

No abstract

Helicobacter pylori (H. pylori) infection is associated with the development of multiple diseases. The eradication rate of H. pylori has gradually decreased, suggesting the need to discover more effective therapies. This study aimed to compare the effectiveness of first-line treatments including high-dose dual therapy (HDDT), bismuth-based quadruple therapy (BQT), sequential therapy (ST), concomitant therapy (CT) and hybrid therapy (HT) by network meta-analysis (NMA). A comprehensive search on PubMed, Embase, Cochrane Library and Web of Science, was performed from their inception to 1 September 2019. A network analysis of randomized controlled trials (RCTs) comparing first-line therapies were carried out using Stata 14.0 and Revman 5.2. Moreover, a sensitivity analysis was conducted by omitting non-Asian studies. Finally, 41 RCTs with 14 119 patients were included. The NMA showed that, in terms of eradication rate, ST for 10 days (ST-10) was significantly lower than CT for 10 or 14 days (CT ≥ 10). Sensitivity analysis among the Asian population showed that ST-10 denoted the lowest effectiveness among the interventions. The ranking results based on probability showed that HDDT ranked first for the eradication rate. As for adverse events, HDDT was significantly less than BQT and CT regardless of duration, while BQT for 14 days represented higher adverse events than ST, HT and CT ≥ 10. HDDT ranked first among the therapies. In conclusion, HDDT for 14 days appeared to be the most optimal first-line therapy for H. pylori among the Asian population with comparable efficacy and compliance but causing fewer adverse events.

Objective: To compare the diagnostic accuracy of different hormonal biomarkers and to find the most effective hormonal biomarker for the diagnosis of endometriosis. Data Sources: We conducted a systematic search using PubMed, EMBASE, Cochrane Library, and China Biomedical Literature to identify relevant studies from the first day of databases to August 2018. Methods of Study Selection: Two independent reviewers screened for study eligibility and extracted data. Random controlled trials, cross-sectional studies, case-control studies, and cohort studies evaluating the diagnostic accuracy of hormonal markers for endometriosis were included. Tabulation, Integration, and Results: We included 17 studies that involved 1279 participants and evaluated 7 hormonal biomarkers. The pooled sensitivity and specificity in endometriosis were .79 (.71, .86) and .89 (.82, .94) for aromatase, .30 (.18, .46) and .80 (.65, .90) for human chorionic gonadotropin/luteinizing hormone receptor, .75 (.66, .83) and .47 (.34, .60) for estrogen receptor (ER)-a, .65 (.56, .74) and .68 (.55, .80) for ER-b, .45 (.38−.52) and .92 (.85−.97) for serum prolactin, .69 (.51, .83) and .30 (.16, .49) for estrogen sulfotransferase, and .73 (.60−.84) and .48 (.33−.63) for 17b-hydroxysteroid dehydrogenase type 2 (17bHSD2).Compared with human chorionic gonadotropin/luteinizing hormone receptor, ER-a, ERb, estrogen sulfotransferase, and 17bHSD2, aromatase had a higher sensitivity, specificity, positive likelihood ratio, and diagnostic odds ratio. The specificities of aromatase and serum prolactin were comparable, but the sensitivity, positive likelihood ratio, and positive likelihood ratio of serum prolactin were much lower than that of aromatase. Conclusion: Aromatase may be an excellent diagnostic test for endometriosis. However, because of the moderate quality of the included studies and the limited sample size, this result requires more research to validate.

“Introducing grass into fields”, the major approach to modern grassland agriculture, is the crucial direction of agricultural structure adjustment in the farming-pastoral zone of Northern China. However, there have been few studies on the environmental impacts of agricultural production in this pattern. We used the life cycle assessment (LCA) method for the first time from the perspective of the entire industry chain from agricultural material production to livestock marketing, which involves the combination of planting and breeding. A comparative analysis of the environmental impact processes of beef and pork, the main products of the two existing agricultural systems in Eastern Gansu, was conducted. The findings showed that based on the production capacity of the 1 ha land system, the comprehensive environmental impact benefit of the grassland agricultural system (GAS) in the farming-pastoral zone was 21.82%, higher than that of the cultivated land agricultural system (CLAS). On Primary energy demand (PED) and environmental acidification potential (AP), the GAS needs improvement because those values were 38.66% and 22.01% higher than those of the CLAS, respectively; on global warming potential (GWP), eutrophication potential (EP), and water use (WU), the GAS performed more environment-friendlily because those values were 25.00%, 68.37%, and 11.88% lower than those of the CLAS, respectively. This indicates that a change in land use will lead to a change in environmental impacts. Therefore, PED and AP should be focused on the progress of grassland agriculture modernization by “introducing grass into fields” and new agricultural technologies.