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Wearable electronics have enriched daily lives by providing smart functions as well as monitoring body health conditions. However, the realization of wearable electronics with personal healthcare and thermal comfort management of the human body is still a great challenge. Furthermore, manufacturing such on-skin wearable electronics on traditional thin-film substrates results in limited gas permeability and inflammation. Herein, we proposed a personal healthcare and thermal management smart textile with a three-dimensional (3D) interconnected conductive network, formed by silver nanowires (AgNWs) bridging lamellar structured transition-metal carbide/carbonitride (MXene) nanosheets deposited on nonwoven fabrics. Benefiting from the interconnected conductive network synergistic effect of onedimensional (1D) AgNWs bridging two-dimensional (2D) MXene, the strain sensor exhibits excellent durability (>1500 stretching cycles) and high sensitivity (gauge factor (GF) = 1085) with a wide strain range limit (∼100%), and the details of human body activities can be accurately recognized and monitored. Moreover, thanks to the excellent Joule heating and photothermal effect endowed by AgNWs and MXene, the multifunctional smart textile with direct temperature visualization and solar-powered temperature regulation functions was successfully developed, after further combination of thermochromic and phase-change functional layers, respectively. The smart textiles with a stretchable AgNW-MXene 3D conductive network hold great promise for next-generation personal healthcare and thermal management wearable systems.

Clinical evidence has established that concomitant traumatic brain injury (TBI) accelerates bone healing, but the underlying mechanism is unclear. This study shows that after TBI, injured neurons, mainly those in the hippocampus, release osteogenic microRNA (miRNA)-enriched small extracellular vesicles (sEVs), which targeted osteoprogenitors in bone to stimulate bone formation. We show that miR-328a-3p and miR-150-5p, enriched in the sEVs after TBI, promote osteogenesis by directly targeting the 3′UTR of FOXO4 or CBL, respectively, and hydrogel carrying miR-328a-3p-containing sEVs efficiently repaires bone defects in rats. Importantly, increased fibronectin expression on sEVs surface contributes to targeting of osteoprogenitors in bone by TBI sEVs, thereby implying that modification of the sEVs surface fibronectin could be used in bone-targeted drug delivery. Together, our work unveils a role of central regulation in bone formation and a clear link between injured neurons and osteogenitors, both in animals and clinical settings.

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