No abstract

DABCO-mediated [3 + 2] cycloadditions of donor-acceptor cyclopropanes with aldehydes under solvent-free conditions have been developed for the preparation of fully substituted furans which are a wide range of structurally interesting and pharmacologically significant compounds. The reaction appears to be general for a variety of 1-cyanocyclopropane-1-carboxylates and aldehydes and tolerates the presence of aromatic moieties with electron-withdrawing and electron-donating substituents.

The diversity-oriented synthesis of 2,4,6-trisubstituted pyridines via K2CO3-promoted multicomponent reactions of the β-nitrostyrenes, available substituted salicylic aldehydes and ammonium acetate have been developed.

A diversity-oriented synthesis of 1H-pyrazole derivatives via Brönsted acid-promoted annulations of 1-cyanocyclopropane-1-carboxylates with arylhydrazines has been developed.

An efficient and straightforward method has been developed for the preparation of 1-carbamoylcyclopropane-1-carboxylate derivatives via selective hydrolysis of 1-cyanocyclopropane-1-carboxylates by using hydroxylamine and sodium acetate system strategy. The structure of 1-carbamoylcyclopropane-1-carboxylate 2a was further confirmed by X-ray single crystal analysis.