SUMMARY:Persea americana (avocado) is widely grown in parts of Southeastern Nigeria and used as a medicinal plant in the treatment of several ailments by alternative medical practitioners but very little research has been carried out on its pharmacotoxicity. This study therefore intends to study the histopathologic effect(s) of Persea americana aqueous leaf extract on the liver and kidneys of rabbits. Fresh leaves of Persea americana were processed using the Soxhlet extraction to obtain the aqueous extract. Three (3) groups of weaner rabbits namely the control, the recommended dose and the high dose groups were given water, 75mg/kg/ and 150mg/kg per day of the extract respectively for 28 days. The animals were sacrificed, the liver and kidney were harvested, fixed in 10% buffered formol saline, processed into paraffin wax, sectioned at 5µm and stained by the Haematoxylin and Eosin method and Perl's Prussain Blue method. Slightly better weight gain by the experimental groups suggests that the extract enhances appetite. Histopathology of the liver and kidney of the recommended and high dosage groups were not different from the control group suggesting that the plant extract is beneficial except for the observed loose stool, suggesting increased bowel emptying. This however did not affect weight gain.