The adverse reactions of warfarin that were found mainly occurred in the first month. This study was carried out to observe the effect of gene polymorphisms on the warfarin therapy at the initial stage. Four-hundred and sixty Chinese patients began warfarin treatment with daily 2.5 mg after heart valve replacement operations were enrolled. The daily international normalized ratio (INR) for anticoagulation were recorded till the seventh day. Blood samples were collected and used to detect genotypes for VKORC1 rs7294, CYP2C9 rs1057910, CYP4F2 rs2108622 and ORM1 rs17650. INR and their changes were compared among genotypes. INR was partially correlated with the VKORC1 rs7294, CYP2C9 rs1057910, CYP4F2 rs2108622 and ORM1 rs17650 polymorphisms from the third, fourth and sixth day on, respectively. VKORC1 rs7294 and CYP4F2 rs2108622 carriers responded lower than the wild genotype, whereas CYP2C9 rs1057910 and ORM1 rs17650 carriers responded higher, respectively. Fifty percent of AA/*1*3/CC/*S*S patients and 16% of AA/*1*1/CC/*S*S patients were over anticoagulation treated with INR >4.0 at the third day. Ninety percent of VKORC1 rs7294 carrier patients have INR <1.63, a mark of the 25% of lower responders of the wild genotype. Our study provided another kind of evidence that VKORC1 rs7294, CYP2C9 rs1057910, CYP4F2 rs2108622 and ORM1 rs17650 affected the action of warfarin in different styles. Patients with AA/*1*1/CC/*S*S, AA/*1*3/CC/*S*S should use a less initial dosage to avoid over anticoagulation, and patients with VKORC1 rs7294 should use larger initial dose to proof an effective therapy.

The effects of yttrium (0, 2?5, 4?0 and 6?0 wt-%) on the microstructures, age hardening behaviours and mechanical properties of the Mg-2?4Nd-0?2Zn-0?4Zr alloys were investigated. The results demonstrated that the Mg-2?4Nd-0?2Zn-0?4Zr alloy was mainly composed of a-Mg and Mg 12 Nd phases. When Y was the added into Mg-2?4Nd-0?2Zn-0?4Zr alloy, Mg 24 Y 5 phases formed. The volume fraction of Mg 24 Y 5 phases increased, and the grains were refined with the Y element increasing. Moreover, the additions of Y could improve the peak aged hardness and mechanical properties of the alloys. Mg-2?4Nd-0?2Zn-0?4Zr-6Y alloy exhibited the highest yield strength of 280 MPa in 225uC peak aged condition; Mg-2?4Nd-0?2Zn-0?4Zr-4?0Y alloy exhibited the optimal mechanical properties in the peak aged condition, whose value of ultimate tensile strength, yield strength and elongation were 330 MPa, 265 MPa and 6?5% respectively. The optimal mechanical properties of Mg-2?4Nd-0?2Zn-0?4Zr-4?0Y alloy were mainly attributed to the high volume fraction of fine metastable b9 precipitates in the matrix and the discontinuous distribution of the sparse grain boundary precipitates along grain boundary.