The NLR measured at admission can serve as an independent predictor for 3-month mortality rate in AoCLF patients.

1The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive 2 and clinical neuroscience. Contemporary explorations are founded upon neuropsychological 3 investigations of semantic dementia (SD) that describe the patients' selective semantic 4 impairment and the variations in their language, behavioural and face recognition abilities. 5 The purpose of this investigation was to generate a single unified model which captures the 6 known cognitive-behavioural variations in SD, and integrates with the considerable database 7 on healthy semantic function and other patient groups. A new analytical approach was able to 8 capture the graded neuropsychological differences and map these to the patients' distribution 9 of frontotemporal atrophy. Multiple regression and principal component analyses confirmed 10 that the degree of generalised semantic impairment was related to the patients' total, bilateral 11 ATL atrophy. Verbal production and word-finding abilities were related to total ATL atrophy 12 as well as to the balance of left>right ATL atrophy. Behavioural apathy was found to relate 13 positively to the degree of orbitofrontal atrophy and negatively to total temporal volumes. 14 Disinhibited behaviour was related to right ATL and orbitofrontal atrophy and face 15 recognition to right ATL volumes. Rather than positing mutually-exclusive sub-categories, 16 the data-driven model repositions semantics, language, social behaviour and face recognition 17 into a continuous frontotemporal neurocognitive space. 18 19 Keywords: semantic dementia, anterior temporal lobe, principle component analysis, 20 laterality, graded model 21 22 Recent years have shown a considerable increase of interest in the cognitive and 2 behavioural functions of the anterior temporal lobes (ATL). This heightened attention on the 3 ATL is founded upon the unique insights that arise from detailed neuropsychological and 4 neurological investigations of semantic dementia (SD; the temporal-variant of frontotemporal 5 dementia) 1-5 . These findings have, in turn, inspired cognitive neuroscience explorations of the 6 contribution of the ATL to semantic representation in healthy participants 6-10 , comparative 7 studies across different patient groups with impaired semantic performance 11-16 and formal 8 neuroanatomically-constrained computational models of semantic cognition 17-21 . The purpose 9 of this investigation was to go beyond these descriptions to generate, for the first time, a 10 unified neurocognitive model of ATL function which captures the known 11 cognitive-behavioural variations across SD, maps these to the underlying patterns of atrophy, 12 and integrates with the considerable database on the graded bilateral ATL contributions to 13 healthy semantic function 22 and semantic impairment in other patient groups 23 . In doing so, 14 this approach accommodates the facts that: (a) there are not mutually-exclusive subtypes of 15 SD but rather gradely-varying patterns of cognitive-behavioural presentation; (b) SD ...

No abstract