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One of the main objectives of a clinical laboratory is getting accurate values. To quantify the hemolysis, the study of hemolytic index is a widespread practice. Due to a change of analyzers, the present hemolysis interference study is aiming to quantify the possible change in 73 tests performed by different techniques in such equipment: spectrophotometry, indirect potentiometric and immunological techniques. The tests were performed in Roche Diagnostics Cobas 8000 equipment following the protocol of the Spanish Society of Laboratory Medicine (SEQCml). The results were compared with those reported in the inserts provided by Roche Diagnostics of the different techniques. Interference was obtained for the following compounds: amylase, aspartate aminotransferase (AST), direct bilirubin (DBil), creatinine kinase (CK), alkaline phosphatase (ALP), iron, lactate dehydrogenase (LDH), lipase, phosphorus, potassium, triglycerides, folate, ultrasensitive troponin T (hs-cTnT), insulin and parathyroid hormone (PTH). Working with new analyzers, it is important to study the interference of the hemolysis on different analytical techniques, as it has an impact on the medical decision making. In clinical practice, it is recommended to determine the hemolytic index, to detect and quantify the interference by hemolysis, assessing the possible rejection of samples and providing reliable reports helping clinicians to interpret the results.

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