SYNOPSISThe effects of diazepam, clomipramine, and chlorpromazine upon cerebral metabolism and blood flow were examined separately in 18 dogs. After the administration of diazepam or clomipramine, cerebral cortical oxygen consumption (CMRO2) decreased significantly by a maximum of 17% and 13% of control within 10 minutes and 15 minutes, and returned to control at 120 minutes and 90 minutes, respectively. Chlorpromazine, however, decreased by a maximum of 10% of control, a level which continued throughout the period of observation. It was observed that reduction in CMRglucose was followed by the reduction in CMRO2 at an interval during the early stages of CMRO2 depression. Diazepam produced a significant decrease in CBF accompanied by a reduction in CMRO2, but neither clomipramine nor chlorpromazine had any effect on CBF in spite of reduction in CMRO2. Reduction in CMRO2 both with diazepam and clomipramine was accompanied by slow wave activities of EEG, but with chlorpromazine reduction in CMR02 was accompanied with less pronounced slow wave activities. It was concluded that the three drugs examined were cerebral metabolic depressants.It has been generally assumed that the effects of psychotropic drugs upon the central nervous system are related to their therapeutic action in patients with psychiatric disorder. This assumption follows from extensive pharmacological, biochemical, and electrophysiological studies obtained with these drugs. In the present study we examined the effect of three psychotropic drugs-diazepam, clomipramine, and chlorpromazine-on the canine cerebral metabolism and circulation.Although the effects of chlorpromazine on cerebral oxygen consumption have been extensively investigated in animals (Frowein et al., 1955) or men (Fazekas et al., 1955;Morris et al., 1955;Aizawa et al., 1956;Moyer et al., 1956;Ehrmantraut et al., 1957;Sutherland et