In contrast to conventional X-ray therapy, proton beam therapy (PBT) can confine radiation doses to tumours because of the presence of the Bragg peak. However, the precision of the treatment is currently limited by the uncertainty in the beam range. Recently, a unique range verification methodology has been proposed based on simulation studies that exploit spherical ionoacoustic waves with resonant frequency (SPIREs). SPIREs are emitted from spherical gold markers in tumours initially introduced for accurate patient positioning when the proton beam is injected. These waves have a remarkable property: their amplitude is linearly correlated with the residual beam range at the marker position. Here, we present proof-of-principle experiments using short-pulsed proton beams at the clinical dose to demonstrate the feasibility of using SPIREs for beam-range verification with submillimetre accuracy. These results should substantially contribute to reducing the range uncertainty in future PBT applications.

We present the general properties of multihadron final states produced by e + e annihilation at center-of-mass energies from 52 to 57 GeV in the AMY detector at the KEK collider TRISTAN. Global shape, inclusive charged-particle, and particle-flow distributions are presented. Our measurements are compared with QCDS-fragmentation models that use either leading-logarithmic parton-shower evolution or QCD matrix elements at the parton level, and either string or cluster fragmentation for hadronization.

Purpose Ionoacoustics is one of the promising approaches to verify the beam range in proton therapy. However, the weakness of the wave signal remains a main hindrance to its application in clinics. Here we studied the potential use of a fixed‐field alternating gradient accelerator (FFA), one of the accelerator candidates for future proton therapy. For such end, magnitude of the pressure wave and range accuracy achieved by the short‐pulsed beam of FFA were assessed, using both simulation and experimental procedure. Methods A 100 MeV proton beam from the FFA was applied on a water phantom, through the acrylic wall. The beam range measured by the Bragg peak (BP)‐ionization chamber (BPC) was 77.6 mm, while the maximum dose at BP was estimated to be 0.35 Gy/pulse. A hydrophone was placed 20 mm downstream of the BP, and signals were amplified and stored by a digital oscilloscope, averaged, and low‐pass filtered. Time‐of‐flight (TOF) and two relative TOF values were analyzed in order to determine the beam range. Furthermore, an acoustic wave transport simulation was conducted to estimate the amplitude of the pressure waves. Results The range calculated when using two relative TOF was 78.16 ± 0.01 and 78.14 ± 0.01 mm, respectively, both values being coherent with the range measured by the BPC (the difference was 0.5‒0.6 mm). In contrast, utilizing the direct TOF resulted in a range error of 1.8 mm. Fivefold and 50‐fold averaging were required to suppress the range variation to below 1 mm for TOF and relative TOF measures, respectively. The simulation suggested the magnitude of pressure wave at the detector exceeded 7 Pascal. Conclusion A submillimeter range accuracy was attained with a pulsed beam of about 21 ns from an FFA, at a clinical energy using relative TOF. To precisely quantify the range with a single TOF measurement, subsequent improvement in the measuring system is required.

Kumatori Accelerator driven Reactor Test project (KART) has been started at Kyoto University Research Reactor Institute (KURRI) from the fiscal year of 2002, aiming to demonstrate the basic feasibility of Accelerator Driven Sub-critical Reactor system (ADSR) and to develop an 150 MeV proton Fixed Field Alternating Gradient (FFAG) accelerator complex as a neutron production driver. This FFAG complex will be connected with our Kyoto University Critical Assembly (KUCA) by the end of March 2006 for the basic ADSR experiments.

No abstract