Objectives-To investigate the relationship between visceral fat thickness measured by US and the estimated glomerular filtration rate (GFR) in patients with obesity who did not have hypertension or diabetes and who had normal renal function.Methods-Inclusion criteria included an estimated GFR of greater than 90 mL/ min/1.73 m 2 , blood pressure lower than 120/80 mm Hg, and a fasting blood glucose level of less than 126 mg/dL. Patients were divided into groups with (body mass index ≥28 kg/m 2 ) and without (body mass index <28 kg/m 2 ) obesity. Subcutaneous and visceral fat thicknesses were measured with ultrasound.Results-A total of 95 patients were enrolled with an age range of 25 to 58 years. The patients were divided into groups with (n = 48) and without obesity (n = 47); patients with obesity were further divided into subcutaneous obesity (n = 23) and visceral obesity (n = 25) groups. The estimated GFR in the group with obesity was significantly lower than that in the group without obesity (P = .037), and the estimated GFR in the group with visceral obesity was significantly lower than that in the group with subcutaneous obesity (P = .006). Moreover, the estimated GFR was negatively correlated with visceral fat thickness (V1:r = −0.750;P7 < 0.001;V2: r = −0.824;P < 0.001) but not correlated with subcutaneous fat thickness.Conclusions-Ultrasound is an easy and accurate practical evaluation modality for measuring the thickness of fat. There was an inverse relationship between the estimated GFR and visceral fat thickness in patients with obesity who did not have hypertension or diabetes and who had normal renal function. This result suggests that as visceral fat increases, the estimated GFR may be reduced accordingly.
Objective
To determine if the artificial intelligence‐based Thyroid Imaging, Reporting and Data System (AI TIRADS) would perform better than the American College of Radiology (ACR) TIRADS in monitoring malignant thyroid nodules not recommended for biopsy using follow‐up thresholds.
Methods
A total of 3499 thyroid nodules with surgical histopathology and ultrasound features were retrospectively reviewed and categorized using ACR TIRADS and AI TIRADS. The recommendations for biopsy and follow‐up divided nodules into three groups 1) fine needle aspiration (FNA), 2) follow‐up ultrasound, and 3) no further evaluation.
Results
Of the total 1608 malignant nodules in this study, 974 malignant nodules would not be biopsied in ACR TIRADS compared with 967 in AI TIRADS. While 60.0% (584/974) of these non‐biopsied malignancies could be followed‐up by ultrasound in ACR TIRADS and 62.8% (607/967) in AI TIRADS. For the malignancies of no further evaluation, 97.4% (380/390) were sized <10 mm in ACR TIRADS and 93.3% (336/360) in AI TIRADS. Compared with ACR TIRADS, AI TIRADS had lower unnecessary FNA rate and missing cancer rate (41.0% vs 47.8% and 22.8% vs 27.5%, P < .05, respectively) while having higher specificity and AUC as well as lower sensitivity (65.0% vs 57.9%, 0.895 vs 0.881, and 96.1% vs 97.8%, all P < .05).
Conclusions
Using the follow‐up thresholds, more than half of the malignancies not being biopsied were monitored by ultrasound in both ACR TIRADS and AI TIRADS, and AI TIRADS had lower missing cancer rate. More than 90% of malignancies recommended for no further evaluation were <10 mm in diameter.
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