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In previous work, it was found that the bovine serum albumin (BSA) could obviously be damaged by nano sized TiO 2 powder as a sonocatalyst under ultrasonic irradiation. In this work, metronidazole (MTZ) was adopted as a sensitizer to intensify the damage of BSA molecules. It was found that the damage degree of BSA molecules in the presence of MTZ was more serious than in the absence of MTZ. That is, under ultra sonic irradiation combined with nano sized TiO 2 powder, the addition of MTZ could remarkably aggravate the damage to BSA molecules. Meanwhile, the damage degree was also affected by some influence factors, such as ultrasonic irradiation time, ultrasonic irradiation power, MTZ concentration, solution acidity, ionic strength and solution temperature. In addition, the damage site of BSA molecules was also estimated by syn chronous fluorescence spectra. It was found that the damage site of BSA molecules was mainly at tyrosine (Tyr) residue. WANG et al.Several influence factors, such as ultrasonic irradia tion time, ultrasonic irradiation power, MTZ concen trations, solution acidity, solution temperature, ionic strength and ionic kind on the damage of BSA mole cules were also reviewed by the analysis of UV vis and fluorescence spectra. Perhaps, these research results are important for driving sonocatalytic method to treat tumors in the future.