Background: This study aimed to evaluate the clinical efficacy of apatinib combined with capecitabine in advanced triple-negative breast cancer patients who failed secondline treatment. Methods: From October 2015 to April 2017, we retrospectively screened 53 patients who had been diagnosed with advanced triple-negative breast cancer in our hospital. Experimental group: 26 patients with apatinib (250 mg, qd, orally) and capecitabine (1250mg/m 2 , bid, d1-14, orally), treatment was continued until disease progression. Control group :27 patients with capecitabine (1250mg/m 2 , bid, d1-14, orally). The objective response rate, disease control rate and adverse events of the two groups were compared.Results: The objective response rate and disease control rate in the experimental group was significantly higher than in the control group. The objective response rateswere 30.8% and 3.7%, respectively. The disease control rates were 65.4% and 29.6%, respectively. There were no significant differences in the adverse events between the two groups except grade I-II hypertension and I-II bleeding. Conclusions: Apatinib combined with capecitabine is efficacious in treating patients with triple-negative breast cancer who failed second-line treatment, with acceptable toxic effects. Legal entity responsible for the study: Yihui Li. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.

Chinese herbal medicine Jinlianqingre Effervescent Tablets (JET) are the recommended control measure for uncomplicated hand, foot, and mouth disease (HFMD) by the Ministry of Health of China. However, high-quality evidence to support this recommendation is limited. A total of 288 patients ranging in age from 1 to 13 years were randomly assigned to JET in combination with conventional therapy (mainly including the reduction of temperature by applying physical cooling paste or warm bathing), or conventional therapy with placebo group for 7 days. The objective was to test the hypothesis that JET combination therapy is more effective than conventional therapy for uncomplicated HFMD. A randomized, double-blind, placebo-controlled trial was designed. Our study showed that, compared with conventional therapy, the median time to fever resolution was significantly shorter in the JET combination therapy (8 vs. 80 h; p < 0.0001); the risk of fever resolution increased in the JET combination therapy [hazard ratio, 19.8; 95% confidence interval (CI), 12.8 to 30.7]; the median healing time of rash or oral ulcer was significantly shorter in the JET combination therapy (14 vs. 74 h; p < 0.0001); and the median symptom score for skin or oral mucosa lesions improved more rapidly in the JET combination therapy during the follow-up period. The median duration of hospital stay was 6 days in the JET combination therapy and 7 days in the conventional therapy (p < 0.0001). No significant adverse events and complications were found in both groups. The addition of JET to conventional therapy reduced fever clearance time, healing time of skin or oral mucosa lesions, and duration of hospital stay in children with uncomplicated HFMD.

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