The first direct observation of a chemically heterogeneous nanostructure within an epoxy resin is reported. Epoxy resins comprise the matrix component of many high performance composites, coatings and adhesives, yet the molecular network structure that underpins the performance of these industrially essential materials is not well understood. Internal nodular morphologies have repeatedly been reported for epoxy resins analysed using SEM or AFM, yet the origin of these features remains a contentious subject, and epoxies are still commonly assumed to be chemically homogeneous. Uniquely, in this contribution we use the recently developed AFM-IR technique to eliminate previous differences in interpretation, and establish that nodule features correspond to heterogeneous network connectivity within an epoxy phenolic formulation.

Lithium carbonate and lithium oxalate were incorporated as leachable corrosion inhibitors in model organic coatings for the protection of AA2024-T3. The coated samples were artificially damaged with a scribe. It was found that the lithium-salts are able to leach from the organic coating and form a protective layer in the scribe on AA2024-T3 under neutral salt spray conditions. The present paper shows the first observation and analysis of these corrosion protective layers, generated from lithium-salt loaded organic coatings. The scribed areas were examined by scanning and transmission electron microscopy before and after neutral salt spray exposure (ASTM-B117). The protective layers typically consist of three different layered regions, including a relatively dense layer near the alloy substrate, a porous middle layer and a flake-shaped outer layer, with lithium uniformly distributed throughout all three layers. Scanning electron microscopy and white light interferometry surface roughness measurements demonstrate that the formation of the layer occurs rapidly and, therefore provides an effective inhibition mechanism. Based on the observation of this work, a mechanism is proposed for the formation of these protective layers.

Aims High-density lipoprotein (HDL) protects against atherosclerosis development. Defective functioning of HDL in Type 2 diabetes may be one cause of increased cardiovascular disease associated with Type 2 diabetes. HDL modulates low-density lipoprotein and cell membrane oxidation through the action of paraoxonase-1 (PON1), which is one of the major mechanisms by which HDL is anti-atherogenic. MethodsWe have compared the ability of HDL from Type 2 diabetic patients without coronary heart disease (CHD) ( n = 36) to metabolize membrane lipid hydroperoxides with HDL from healthy control subjects ( n = 19) and people with CHD but no diabetes ( n = 37).Results HDL from subjects with Type 2 diabetes and CHD metabolized 20% less membrane hydroperoxides than HDL from control subjects ( P < 0.05). The PON1-192RR was least efficient in all the study groups. PON1 was glycated in vivo : (7.5% control, 12% CHD, 17% Type 2 diabetes P < 0.01) with QQ isoforms most glycated. In vitro glycation of PON1 reduced its ability to metabolize membrane hydroperoxides by 50% ( P < 0.001); however, glyoxidation reduced it by 80% ( P < 0.001). In the control group only there was a significant negative correlation between PON1 activity and the ability of HDL to metabolize membrane hydroperoxides ( r = − 0.911, P < 0.001).Conclusions HDL from Type 2 diabetic patients without CHD has decreased ability to metabolize membrane lipid hydroperoxides, which could lead to increased susceptibility to cardiovascular disease.

Near-surface deformed layers, which are characterized by nano-sized fine grains, are generated in aluminum alloys by hot and cold rolling. During the rolling processes, the alloy surface and near-surface regions experience a high level of shear deformation that results in significant microstructure refinement, leading to formation of near-surface deformed layers with microstructures different from that of the underlying bulk alloy. Two types of near-surface deformed layers are observed. Type A is characterized by fine grains with grain boundaries decorated by oxide particles; type B is characterized also by fine grains but with the grain boundaries free of oxide particles. The high levels of shear deformation result in dynamic recrystallization. Together with mechanical alloying, this is responsible for the formation of the near-surface deformed layer. Furthermore, the structure in the near-surface deformed layer can survive the typical annealing process particularly if the grain boundaries are pinned by oxide particles.