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Shashlik tower, which is composed of absorbers and scintillators alternately, surrounded by reflector and coupled with Silicon Photomultiplier (SiPM) by Wavelength-Shifting (WLS) fibers, is a significant component to measure the energy and position of photons and electrons in Electromagnetic Calorimeter (ECal), a key detector of the Multi Purpose Detector (MPD) at the Nuclotron-based Ion Collider facility (NICA) in Russia. In this paper, the effect of materials adopted for absorber, reflector and WLS fiber, the length and curvature of fibers and the electrons incident position on photons transmission performance of tower is simulated based on GEANT4 software. The impact of Gaussian deviation's electron beam energy and spread of 10% in the energy range on the energy resolution of tower is also studied. Results show that the low polishing degree absorber, the high polishing degree TiO_2 reflector and the type of Y-11 WLS fibers bent with a curvature radius of greater than 11 cm can significantly improve the light output. In addition, electrons injected along the centre of tower can make photons position distribution in SiPM more uniform. The generation time of photons in scintillators and time of arrival at the SiPM both obey the Landau distribution. Finally, the energy resolution of tower can be better than 3.8%/√(E) (GeV) for a Gaussian deviation's electron beam with an average energy of 3 GeV and spread of 10% in the energy range.

The Jiangmen Underground Neutrino Observatory (JUNO), a 20 kton multipurpose underground liquid scintillator detector, was proposed for the determination of the neutrino mass hierarchy as primary physics goal. The central detector will be submerged in a water Cherenkov detector to lower the background from the environment and cosmic muons. Radon is one of the primary background sources. Nitrogen will be used in several sub-systems, and a highly sensitive radon detector has to be developed to measure its radon concentration. A system has been developed based on 222Rn enrichment of activated carbon and 222Rn detection based on the electrostatic collection. This paper presents the detail of a μBq/m3 level 222Rn concentration measurement system and gives detailed information about how the adsorption coefficient was measured and how the temperature, flow rate, and 222Rn concentration affect the adsorption coefficient.

Background:Compliance to urate-lowering therapy (ULT) is poor in gout patients, which contributes to increased frequency of acute gout attacks, deposition of tophi and urate nephropathy [1]. Optimistic status is probably a potential and considerable factor affecting compliance to ULT in gout patients.Objectives:To compare optimistic status between gout patients and healthy controls, and also between gout patients with good and poor compliance. Relationship between optimistic status and compliance to ULT, sUA target achievement of gout patients were assessed as well.Methods:This was a monocentric and observational study which was performed from August 2018 to December 2019. Adult patients who met the 2015 gout classification criteria were included in this study. The healthy controls were individuals who were free of gout, hyperuricemia and other rheumatic diseases from the physical examination center of our hospital. Demographic data, including age, gender and education were collected from all individuals. Serum uric acid (sUA) were collected from gout patients at enrollment and again after 3 months. Disease duration of gout, visual analogue scale (VAS) of pain were also assessed for gout patients at enrollment. Compliance to ULT was measured using the medication possession ratio (MPR) in the following 3 months. Poor compliance was defined as MPR<0.8 and good compliance was defined as MPR≥0.8. All subjects completed the life orientation test-revised (LOT-R) for optimistic status assessment.Results:Five hundred and thirty gout patients and 307 healthy controls matched by age (41.4±12.3 vs. 42.1±9.3 years), gender (male 97.1% vs. 95.1%) and education (college graduated 54.2% vs. 58.0%) were included in this study. Of the 530 gout patients, the mean disease duration was 5.7±4.9 years, and 292 (55.1%) patients’ MPR were lower than 0.8. There was no statistic difference in LOT-R between gout patients and healthy controls (19.0±2.4 vs. 19.2±2.5, P>0.05) (Table 1). Gout patients with poor compliance (MPR<0.8) had higher level of sUA (525.5±138.0 vs. 471.2±152.5 μmol/L, P<0.05), followup sUA (450.1±154.5 vs. 361.6±120.0 μmol/L, P<0.05) and higher LOT-R (19.6±2.6 vs. 17.8±1.7, P<0.05) than those with good compliance (MPR≥0.8). Of the 292 gout patients with poor compliance, there were only 83 (28.4%) patients achieved sUA target after 3 months, and their LOT-R were significantly lower than those did not achieve sUA target (18.8±2.1 vs. 19.6±2.4, P<0.05). Finally, LOT-R correlated positively with sUA (r=0.131, P<0.05) and followup sUA (r=0.09, P<0.05), but negatively with MPR (r=-0.473, P<0.05) of gout patients (Table 2).Table 1Demographic and optimistic status of gout patients and healthy controlsVariablesGout patients(n=530)Controls(n=307)PAge (years)41.4±12.342.1±9.30.116Male gender, n (%)511 (96.4)292 (95.1)0.368College graduated, n (%)287 (54.2)178 (58.0)0.312LOT-R19.0±2.419.2±2.50.189LOT-R:life orientation test-revisedTable 2Correlation analysis between LOT-R and clinical variables in gout patientsVariablesLOT-RrPAge00.994Disease duration-0.0580.182VAS0.0340.432sUA0.1310.003*Followup sUA0.1260.016*MPR-0.393<0.001*LOT-R: life orientation test-revised,VAS:visual analogue scale,sUA:serum uric acid,MPR:medication possession ratio*P<0.05Conclusion:Gout patients share similar optimistic status to healthy controls. However, optimistic status relates to compliance to ULT and sUA target achievement of gout patients.References:[1]Harrold L R, Andrade S E, Briesacher B A, et al. Adherence with urate-lowering therapies for the treatment of gout. Arthritis research & therapy 2009, 11(2):R46.Disclosure of Interests: :None declared