Calcipotriol exhibits its antipsoriatic function through suppressing A20 expression and stabilizing negative regulators of the NF-κB pathway.

The effects of a coherent mode (CM) at a frequency of f = 13–16 kHz on the redistribution of divertor particle flux have been studied in HL-2A H-mode plasmas using multiple diagnostics. The experimental results demonstrate that a CM localized at the middle of the pedestal results in outward particle transport, limiting the growth of the pedestal density gradient in the recovery phase of the pedestal, leading to a substantial increase in the localized particle flux striking the outer divertor target, which clearly deviates from the primary peak at the strike point. These observations indicate that the CM might play a crucial role in redistributing the divertor particle flux, which is important for understanding and controlling the divertor heat flux in future fusion-relevant devices.

histology. Remarkable is the linear pattern. It is tempting to associate the local treatment of the trigeminal neuralgia with the development of the milia. As the alignment of the milia is not in accordance with the distribution of a trigeminal nerve's branch, a connection seems unlikely. Accessorily, the milia do not follow the lines of Blaschko and ultimately the aetiology of the linear pattern remains unclear.

References1 Assier H, Bastugigarin S, Revel J, Roujeau JC. Clinical classification of cases of Toxic epidermal necrolysis, Stevens-Johnson Syndrome. Arch Dermatol 1993; 129: 92-96. 2 Pereira FA, Mudgil AV, Rosmarin DM. Toxic epidermal necrolysis. J Am Acd Dermatol 2007; 56: 181-200. 3 Mockenhaupl M, Messenheimer J, Tennis P, Schlingmann J. Risk of Stevans-Johnson Syndrome and Toxic Epidermal Necrolysis in new users of antileptics. Neurology 2005; 64: 1134-1138. 4 Eaye O, Wechslor Roujeau JC. Cell-mediated immunologic mechanism and severity of TEN. Arch Dermatol 2005; 141: 775-776. 5 Mackie RM. Cutaneous Lymphomas and lymphocytic infiltrates. In: Rook A, Wilkinson DS, Ebling EJG, eds. Text book of Dermatology, 6th edn. Oxford Blackwell science, 1998: 2374-2382. 6 Miller RA, Coleman CN, Fawcett HD, Hoppe RT, McDougall IR. Sezary Syndrome: a model for migration of T Lymphocytes to the skin. N Eng J Med 1980; 303: 89-92. 7 Nikkels AJ, Sadzot-Delvaux C. Absence of intercellular adhesion molecule 1 expression in varicella zoster virus-infected keratinocytes during herpes zoster. Another immune evasion strategy? Am

References1 Mehta RK, Burrows NP, Rowland Payne CME, Mendelsohn MM, Pope FM, Rytina E. Elastosis perforans serpiginosa and associated disorders. Clin Exp Dermatol 2001; 26: 521-524. 2 Vearrier D, Buka RL, Roberts B, Cunningham B, Eichenfield L, Friedlander S.What is the standard of care in the evaluation of elastosis perforans serpiginosa? A survey of pediatric dermatologists.