An efficient green and sustainable protocol has been devised for the selective oxidative halogenation of acetanilides, benzanilides, sulphonamides, and heterocyclic compounds, using easily available NaX as a halogen source and Oxone as a powerful oxidant. Reaction products were analyzed by GC-MS. Defined experimental conditions provided the mono and dihalo compounds. The present protocol is simple and environmentally benign to conduct the laboratory scale halogenations and can be extended to prepare industrially important compounds.[a] V. M.