Objective This in vitro study investigated the influence of resin coating on the bonding performance of self‐adhesive resin cements in single‐visit computer‐aided design (CAD)/computer‐aided manufacturing (CAM) resin restorations. Materials and method CAD/CAM resin (1.5‐mm thick) was mounted on 20 noncoated and 20 resin‐coated human dentin surfaces using dual‐cured self‐adhesive resin cements (Panavia SA Cement Plus or Panavia SA Cement Universal, Kuraray Noritake Dental) in either self‐curing or dual‐curing mode. These specimens were sectioned into beam‐shaped sticks and subjected to microtensile bond strength tests after 24 h of water storage. The obtained data were statistically analyzed with three‐way analysis of variance (ANOVA) and t tests (α = 0.05). Results The three‐way ANOVA results revealed the significant influence of resin coating, resin cement, and curing mode. Resin coating and light curing led to higher bond strengths in almost all groups. Resin‐coated dentin with Panavia SA Cement Plus exhibited a mean bond strength greater than 35 MPa in both self‐curing and dual‐curing modes. Conclusions In single‐visit CAD/CAM resin restorations, resin coating, resin cement selection, and curing mode influenced the bonding performance of self‐adhesive resin cements. In addition, resin coating and light curing increased the bond strength of self‐adhesive resin cements. Resin coating and light curing are encouraged for predictable bonding performance of dual‐cured self‐adhesive resin cements in single‐visit CAD/CAM resin restorations.