The objective of this study was to assess the effectiveness of variable titration, low-dose intratympanic gentamycin (ITG) into the worse affected ear of patients with bilateral Meniere's disease (MD). It is a prospective analytic case series conducted in a tertiary care referral hospital in a developing economy and a tertiary care otologic private ENT clinic. Patients with MD who failed or are intolerant to medical treatment were recruited based on the criteria of definite MD and bilateral ear involvement. 0.75 cc of low-dose (40 mg/ml) buffered gentamycin was injected into the worse affected ear and patients followed up every 2 months, and the regime repeated only if subjective vertigo persists. The patient's age, sex, duration of MD symptom, ear first affected, ear selected for ITG, pure tone threshold at each visit, duration of caloric response (in seconds) for the injected ear, status of tinnitus in both ipsilateral (injected) and contralateral ears, total number of injections before last follow-up, and time since last follow-up are entered into the study protocol and analyzed. Nine patients with a mean age of 45 years and mean duration of symptoms of 59 months were treated. The mean total number of injections was 2.8 with a mean follow-up period of 34 months. Three cases showed drop in pure tone average threshold (2.5-7.5 dB) while an increase in threshold was noted in six cases (2.5-5 dB). All cases demonstrated decrease in duration of response to iced water caloric stimulation in ipsilateral ear, and 4/9 of contralateral ear. The variable titration method using low-dose intratympanic gentamycin directed at worse ear of adult Nigerians with bilateral Meniere's disease appears to be highly effective. More studies are needed.

VTE results in > 30,000 deaths/ year. Surgical inpatients are at 25% risk of developing VTE. National guidelines state all surgical admissions must be risk assessed for VTE within 24 hours. Aim Evaluate our current practice of VTEP. Create and disseminate interactive tutorials for healthcare professionals (HCPs). Improve patient understanding and adherence to VTEP. Method A baseline audit analysed existing VTEP measures. Inclusion criteria: all ESU admissions, age >18. Parameters included ensuring completion of VTE risk assessment (VTERA) proformas; scrutinizing low-molecular-weight heparin (LMWH) and TED stockings (TEDs) prescriptions; observing patients’ TEDs use and reasons for non-adherence. Subsequently, plan-do-study-act (PDSA) cycles were performed. Results Baseline [September 2020] (n = 93): VTERA complete: 54%; LMWH (57%) and TEDs (37%) prescribed; 26% wearing TEDs; 42% deemed TEDs unnecessary. PDSA Cycle 1 [October 2020] (n = 68): Educational poster displayed in clinical areas. VTERA complete (73.5%), LMWH (75%) and TEDs (53%) prescribing improved. Only 29% wearing TEDs. PDSA Cycle 2 [November 2020] (n = 55): Implementation of VTE e-learning module and inter-professional educational tutorials. HCPs (n = 25) felt more knowledgeable (pre:3.4/5, post:5/5) and confident (pre: 3.2/5, post: 4.7/5) on VTEP. All parameters improved, except patients wearing TEDs (31%). PDSA Cycle 3 [December 2020]: Initial patient questionnaire (n = 30) revealed - 33% misconstrued LMWH use; >50% deemed TEDs unnecessary. A patient information leaflet was created and distributed alongside TEDs. Upon re-audit (n = 72), we noted significant improvement in patient adherence to TEDs (64%), alongside sustained improvement in all other parameters. Conclusions Our initiative highlights the necessity of empowering both patients and the multidisciplinary team in achieving optimum rates of VTEP.