Background: Cardiac marker enzymes are measured to evaluate the heart function. The diagnosis of acute myocardial infarction can be achieved by electrocardiogram (ECG) changes and elevation of cardiac marker enzymes like creatine kinase, lactate dehydrogenase (LDH), aspartate transaminase (AST) and troponin I. Objective: To estimates the levels of AST and troponin I among patients of acute myocardial infarction, and to compare with those among health controls. Materials and Methods: This study was carried out among 50 cases of acute myocardial infarction and 50 age and sex matched healthy individuals. Serum samples of cases, collected after 5 hours and within 24 hours from the onset of chest pain and of controls were analyzed for AST by modified IFCC method and for troponin I by chemiluminescence-sandwich method. Results: The mean levels of AST and troponin I in cases and controls revealed that mean levels of AST and cardiac troponin I in cases (296.02±SD 135.69 IU/L and 57.34±SD 12.83 ng/ml, erspectively) are significantly higher than among controls (25.50±SD 6.22 IU/L and 0.31±SD 0.15 ng/ml, respectively). The differences between cases and controls are statistically significant (p<0.0001). Conclusion: The diagnostic efficiency of AST and troponin I were superior because they are specific to myocardial injury.

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Introduction: Oxidative stress plays an important role in the progression of atherosclerosis, it is the principal cause for coronary artery disease (CAD). Lipid peroxidation product Malondialdehyde (MDA) is an index of oxidative stress. To assess the oxidative stress, MDA and total antioxidant capacity (TAC) are estimated. Body fat distribution was assessed by obesity and blood lipids, which in turn was measured by Body mass index (BMI) and waist circumference (WC). Cystatin C was measured as an emerging cardio vascular risk factor. Materials and Methods: Study consists of two groups, 145 subjects diagnosed with CAD are included in study group and 66 age and sex matched subjects (non CAD) are included in control group. Results: In this study, Cystatin C is highly significant observed in CAD cases than controls. BMI and WC are not significantly increased; whereas significant increase in mean MDA and decrease in mean TAC levels. Conclusion:Oxidative stress is markedly observed in CAD cases, due to toxic effects of ROS. Increase in Cystatin C levels significantly correlated with WC in middle aged individuals.

The epidemic of cardiovascular disease especially coronary heart disease (CHD) is emerging in rural India and accelerating in urban India. Coronary heart disease is the leading cause of death in India; diabetes accounts for a significant burden of CHD events. Trimetazidine (TMZ) is a piperazine derivative with anti-ischaemic properties. It is the first in a new class of metabolic agent, available for clinical use.: To determine the effect of TMZ on blood parameters in normal, hyperlipidemic, diabetic and Streptozotocin induced diabetic hyperlipidemic rats. Adult male albino rats of Wistar strain, weighing approximately 150 to 180 g, were used in the present study. After various treatments, blood was collected from the rats by sinocular puncture for the blood parameters like Fasting blood glucose, urine sugar, HbA1c and Haemoglobin with standard protocols.The levels of blood glucose, HbA1c and urine sugar were found to be elevated in the entire diseased control group than normal control.TMZ has the potential effect against the STZ induced syndromes with an optimum dose of 40 mg/kg in rats.