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SUMMARYBaclofen has been found to bind to receptors in the central nervous system that are specific for 7-aminobutyric acid (GABA), a well known inhibitory neurotransmitter. This paper describes the synthesis of a radioiodinated analog of baclofen as part of an effort to develop receptor probes useful in single photon emission computed tomography. Prel imi nary biodis tr ibut ion studies showed the radioiodinationed analog to be essentially stable to in vivo deiodination and have a distribution profile similar to that of baclof en.

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