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For the Evolved UTRA (EUTRA), in OFDMA uplink, the Inter-cell interference cannot be predicted precisely, so scheduling becomes a puzzling problem and directly affects the uplink performance in OFDMA based system. Previous works [1] [2] [3] did not concern such a problem or just consider single cell environment. In this paper, a novel scheme is proposed that could efficiently solve this problem in multi-cell circumstance. It predefines UEs distributed in the whole cell adopt fixed modulation and coding scheme (MCS) according to the distance from Node B. It employs initial average predictive interference to create the first-loop Inter-cell interference and perform scheduling according to the historical information in the following. Fast power control is adopted in order to compensate the imprecisely predictive inter-cell interference. Soft frequency reuse scheme is adopt in order to improve the cell-edge UE performance. To guarantee the UE fairness, Proportional Fairness (PF) scheduling is adopted in Single Input and Single Output (SISO) environment in this paper.