'Epigenetics' is defined as the inheritable changes in gene expression with no alterations in DNA sequences. Epigenetics is a rapidly expanding field, and the study of epigenetic regulation in cancer is emerging. Disruption of the epigenome is a fundamental mechanism in cancer, and several epigenetic drugs have been proven to prolong survival and to be less toxic than conventional chemotherapy. Promising results from combination clinical trials with DNA methylation inhibitors and histone deacetylase inhibitors have recently been reported, and data are emerging that describe molecular determinants of clinical responses. Despite significant advances, challenges remain, including a lack of predictive markers, unclear mechanisms of response and resistance, and rare responses in solid tumors. Preclinical studies are ongoing with novel classes of agents that target various components of the epigenetic machinery. In the present review, examples of studies that demonstrate the role of epigenetic regulation in human cancers with the focus on histone modifications and DNA methylation, and the recent clinical and translational data in the epigenetics field that have potential in cancer therapy are discussed.

The Western Liaohe River Basin in northeastern China is one of the cradles of ancient Chinese civilization. Archaeological records from this region indicate that human occupation began about 8000 years ago and that agriculture and pastoralism were important activities from an early stage. Very little is known, however, about the effects that these activities had upon the landscape. This paper presents the results of a palaeoecological study from a 3.6 m sedimentary sequence in a relict oxbow lake in the Western Liaohe River Basin of southeast Inner Mongolia. The 5400-yr sequence indicates that human activities had a noticeable impact on an apparently open landscape. Buckwheat cultivation began as early as 5400 cal. yr BP with intensification of agricultural activities from approximately 4700 cal. yr BP. Nitrophilous plants such as Solanum and Cerastium, and also Artemisia were growing in the region at certain times, linked with fluctuations in the d 15 N record and probably indicative of increased pastoralism and unintentional/ intentional manuring. Burning was probably used for clearance of the steppe vegetation for agriculture with a close relationship apparent between increased influx of microfossil charcoal and the presence of buckwheat. Superimposed upon this record of human impact is also clear indication of three significant intervals of climate change between 2900 and 2600, 1200 and 600 and 600 and 30 cal. yr BP. The latter two are discussed in relation to the 'Mediaeval Warm Period' and 'Little Ice Age' apparent in sedimentary sequences across the Northern Hemisphere. Discussions are therefore made in terms of the impact that both climate change and ancient Chinese civilizations had upon shaping the present day landscape and vegetation.

A series of polybenzonitrile derivatives, prepared by plasma glow discharge processes or chemical polymerization, were characterized by FT-IR, UV-Vis, GPC and VPO etc. The secondorder nonlinear optical hyperpolarizability γ of various benzonitrile monomers and their, polymers were measured by the femtosecond time-resolved optical Kerr effect technique, and the structureproperty relationships were discussed. The power law dependence of γ on the averagepolymerization- degree of several polybenzonitrile derivatives were also reported.