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Result window" shows the cartilage information with gray (or color) intensity over the 3D bone shape. The developed program can display and save color DICOM MRI as shown in Fig. 2, and provide the statistical information (Mean, Min, Max of thickness and Volume) of the local VOI of "Lateral Condyle" and "Medial Condyle" as shown in the figures. Conclusions: This paper proposes fully automatic cartilage segmentation and measurement method without any training process. The proposed method can visualize the whole cartilage distribution with the 3D bone shape. The experimental results demonstrate that it can be used for inspecting cartilage damage or loss directly. The developed software is therefore applicable in clinical knee OA diagnosis systems. Future studies include more tests with new MRI data for confirming the accuracy of the measurements.

(PGT). The primary outcome was the live birth rate (LBR). The secondary outcomes were the rates of implantation, ongoing pregnancy, miscarriage, multiple pregnancy, OHSS, ectopic pregnancy, preterm birth, pregnancy-induced hypertension, preeclampsia, birth weight, and congenital anomalies. Subgroup analysis included normal-and hyper-responder patients, embryo development stage on transfer day (cleavage vs. blastocyst), and freezing method (slow-freezing vs. vitrification). We also conducted sensitivity analyses to verify the leverage of individual studies on the pooled results. RESULTS: Eleven studies involving 5,379 patients fulfilled the inclusion criteria for this meta-analysis, and were subjected to qualitative and quantitative analysis. There was an increase in LBR when comparing freeze-all to fresh embryo transfer in the overall IVF/ICSI population (Relative Risk [RR] 1.07; 95% CI 1.01-1.14; I2¼46%; P¼0.02). Subgroup analyses indicated higher LBR with freeze-all than fresh ET in hyper-responders (RR 1.15; 95% CI 1.04-1.27; I2¼0%; P¼0.005) and PGT cycles (RR 1.55; 95% CI 1.14-2.10; P¼0.005). However, there was no differences in LBR in normal responders (RR 1.00; 95% CI 0.93-1.08; I2¼34%; P¼0.94). Sensitivity analyses demonstrated that the benefit of the freeze-all strategy in LBR became no significant by the removal of the PGT study (RR 1.06; 95% CI 1.00-1.12; I2¼22%; P¼0.07). The overall risk of preeclampsia was higher in the freeze-all group (RR 1.78; 95% CI 1.11-2.84; I2¼13%; P¼0.02), mainly due to an increased risk observed in hyper-responders (RR 3.12; 95% CI 1.26-7.73; P¼0.01). There were no statistical differences in all the other outcomes in the overall population. CONCLUSIONS: Although many practitioners have advocated the use of freeze-all strategy, to either the overall IVF population or a specific subset of patients, the benefit of this strategy is only observed in some particular groups of patients, such as hyper-responders and those submitted to PGT. Moreover, the freeze-all policy and subsequent FET may be associated with an increase in the risk of preeclampsia.