Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of the prominent roles is to regulate gene expression. A vast number of circular RNAs (circRNAs) have been identified, and some have been shown to function as microRNA sponges in animal cells. Here, we report a class of circRNAs associated with RNA polymerase II in human cells. In these circRNAs, exons are circularized with introns 'retained' between exons; we term them exon-intron circRNAs or EIciRNAs. EIciRNAs predominantly localize in the nucleus, interact with U1 snRNP and promote transcription of their parental genes. Our findings reveal a new role for circRNAs in regulating gene expression in the nucleus, in which EIciRNAs enhance the expression of their parental genes in cis, and highlight a regulatory strategy for transcriptional control via specific RNA-RNA interaction between U1 snRNA and EIciRNAs.

Supplementary data are available at Bioinformatics online.

Alveolar ridge preservation procedures are effective in minimizing postextraction hard tissue dimensional loss. The outcomes of these procedures are affected by morphology of extraction sockets, type of wound closure, type of grafting materials, use of barrier membranes, and use of growth factors.

Based on the kinetic model of genetic regulation system proposed by Am. J. Physiol. 274, c531 (1998)], the effects of fluctuations in the degradation reaction rate and the synthesis reaction rate of the transcription factor have been investigated through numerical computation and analysis theory. In the case of uncorrelated noises, it is shown that only the fluctuation of degradation reaction rate can induce a switch process, and the mean first passage time (MFPT) from the high concentration state to the low concentration one is decreased when the noise intensity of degradation reaction rate is increased. In the case of correlations between noises, a switch process can also be induced by the cross-correlation intensity between noises and by the fluctuation of the synthesis reaction rate in the genetic regulatory system. It is found that, under large cross-correlation intensity, a successive switch process (i.e., "on" --> "off" --> "on," which we call the reentrance transition or twice switch ) occurs with an increase of noise intensities, and a critical noise intensity exists at which the MFPT of the switch process is the largest. While the system is initially in the high concentration state with an increase of the cross correlation, the stationary probability distribution (SPD) of the transcription factor activator monomer concentration at the low concentration state is increased, yet the MFPT is increased due to the decreasing of the SPD of the transient states between the two steady stable states.