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The influence of local IR irradiation of the experimental melanoma B-16 zone on the distribution of sodium mercaptododecaborate labeled with radioactive iodine ( 131 I-BSH) in mice was studied for two regimes of thermal treatment (before and after administration of the labeled compound). It was established that a considerable increase in the 131 I-BSH content in the model tumor was reached in the case of IR irradiation performed 1 h after drug administration. Based on these data, IR radiation can be considered an effective modifier of 131 I-BSH uptake in tumors, increasing the efficacy of boron-enhanced neutron capture therapy.