In the last decade, high cariesprophylactic efficacy of ammonium hexafluorosilicates, including salts with substituted biologically active ammonium cations, has been demonstrated. Among the promising anti-caries agents are recently synthesized 2-, 3-, 4-carboxymethylpyridinium hexafluorosilicates, for whose cations anti-inflammatory activity is expected. The aim of the work is to assess the presence of anti-inflammatory activity in the series of 2-, 3-, 4-carboxymethylpyridinium hexafluorosilicates in the experiment. 2-, 3-, 4-Carboxymethylpyridinium hexafluorosilicates (I–III, respectively) were synthesized according to the previously proposed technique, carrageenan is a commercial preparation, reference drug is a indomethacin. Experiments on the anti-inflammatory activity of hexafluorosilicates were performed on 77 white Wistar male rats weighing 174–190 g using the carrageenan model of inflammation. The inflammatory reaction was reproduced by subplantary administration of 0.1 ml of a 0.2% solution of carrageenan, the studied compounds were administered orally in doses 1/10, 1/20, 1/50 from LD50 for the compound III. It was established that after administration of carrageenan, animals of the control group showed marked paw edema, which gradually increased and was maximal after 24 hours of observation. According to the data obtained, the indices for compounds I-III practically do not differ from those of the control group. This indicates that, despite the results of the PASS forecast and the presence of acetic acid residue, an anti-inflammatory pharmacofor, in compounds I-III, the compounds under study do not have an anti-inflammatory effect in the carrageenan model. 2-, 3-, 4-Carboxymethylpyridinium hexafluorosilicates do not show the expected anti-inflammatory activity in the carrageenan model of inflammation.

It is known that modern possibilities of pharmacotherapy of various diseases have significantly increased. The search for and creation of effective and safe drugs with a wide range of pharmacological activity remains relevant. Plants of the genus Daucus are a promising plant for a detailed pharmacognostic research. Representatives of the genus have been used for centuries in folk medicine of different countries and exhibit a wide range of medicinal properties. Carrot plants have not been sufficiently studied in phytochemistry and pharmacology. The aim of the study was to analyze the scientific literature and databases of PubMed, Google Scholar on the botanical characteristics, phytochemical composition and medicinal uses of plants of the genus Daucus. The presence of coumarins, phenols, flavonoids, alkaloids, essential oils, carotenoids, ascorbic acid, riboflavin, niacin, thiamine, tocopherol and lutein has been proven in extracts from plant raw materials of different varieties of carrots. The content of biologically active substances can be determined by such factors as variety, temperature, air quality and carbon dioxide content in it, processing and storage. Plants of the genus Carrot (Daucus) are rich in biologically active substances, are actively used in both folk and official medicine, exhibit a wide range of pharmacological properties, including antioxidant, cytotoxic, antitumor, anti-inflammatory, analgesic, antifungal, antibacterial, antiphteric, hepatoprotective, antihypertensive, carminative, diuretic, antispasmodic, wound-healing and immunostimulatory effects. Analysis of the world experience in the use of plants of the genus Daucus in folk medicine, experimental research on the phytochemical composition of plants of the said genus and a wide range of their pharmacological activity showed that aboveground and underground organs of different species of plants of the genus Daucus can be considered promising raw materials for further research on their basis of new phytopreparations of a wide range of action.