İntroduction: Familial Mediterranean fever (FMF) is a hereditary auto-inflammatory disease characterized by recurrent fever and serosal inflammation. Anti-interleukin-1 (Anti-IL-1) treatments are recommended in colchicine resistant and/or intolerant FMF patients. This study aims to evaluate the efficacy of anakinra and canakinumab in FMF patients that are resistant/intolareted to colchicine or complicated with amyloidosis. who were diagnosed with FMF according to the criteria of Tel-Hashomer were included in the study. The laboratory values and clinical features of patients and disease activities were recorded at least every 3 months, and these data were analyzed.Results: Forty-one (63.1%) patients used anakinra (100 mg/day) and 24 (36.9%) patients used canakinumab (150 mg/8 week). The median duration of anti-IL-1 agents use was 7 months (range, 3-30). Fifteen (23.1%) cases were complicated with amyloidosis. Seven (10.8%) patients had renal transplantation. Overall, the FMF 50 score response was 96.9%. In the group that had a glomerular filtration rate (GFR) ≥ 60 ml/min/m 2 , the median proteinuria decreased from 2390 mg/day (range, 1400-7200) to 890 mg/day (range, 120-2750) (p = 0.008). No serious infections were detected, except in one patient.Conclusions: Anti-IL-1 agents are effective and safe in the treatment of FMF patients. These agents are particularly effective at reducing proteinuria in patients with GFR ≥ 60 ml/min/m 2 , but less effective in cases with FMF associated with arthritis and sacroiliitis. Large and long follow-up studies are now needed to establish the longterm effects of these treatments.

The aim of this study is to adapt the Statistics Anxiety Scale (SAS) developed by Vigil-Colet et al. (2008) to Turkish. This study is expected to fill an important gap in the literature since no valid and reliable specific statistics anxiety scale developed or adapted in Turkish for undergraduate students in the literature is available. The sample consists of a total of 439 university students, 258 women and 181 men, studying at Düzce University. The construct validity of the Turkish form of SAS was examined by EFA and DFA. Also, for the criterion validity, a different statistics anxiety scale whose validity and reliability tested was used. As a result of EFA, a three-dimensional structure was obtained as in the structure of the original scale. According to the CFA results, which is the second analysis for construct validity, all fit index results of the model were at an acceptable level. Thus, the CFA results supported the three-factor structure obtained from EFA findings. As a result of the reliability analysis, the Cronbach's Alpha internal coefficients of the SAS and its subscales and, the Guttman and Spearman-Brown internal consistency coefficients of Split-Half Reliability methods were quite high and above the limit of 0.70. For item discrimination, items have good discrimination by obtaining all values above 0.30 lower limit in the results. When the results of the study are evaluated as a whole, the SAS form adapted to Turkish can be used as a guiding scale to measure the statistics anxiety of undergraduate students.

COVID-19 pandemic has caused devastating consequences as psychological traumas especially for healthcare professionals, who play an active role and are at greatest risk in this process. It is important to protect their health to prevent the health system from collapsing. The purpose of this study is to reveal the mediating role of coronavirus fear in the effect of psychological resilience on life satisfaction. coronavirus fear, psychological resilience, and life satisfaction scales were applied to 414 healthcare professionals in 36 provinces of Turkey. The findings show that the increase in the fear of coronavirus decreases the levels of psychological resilience and life satisfaction, whereas the increase in psychological resilience increases the level of life satisfaction. The results suggest that coronavirus fear may contribute to understanding the association between psychological resilience and life satisfaction among healthcare professionals.

Bu çalışma 13-15 Nisan 2016 tarihlerinde Kazakistan'ın Türkistan şehrinde gerçekleştirilen 5. Uluslararası Bilim Kültür ve Spor Kongresi'nde bildiri olarak sunulmuştur.

Purpose of the research is to evaluate the attitudes, hesitancy and confidence of healthcare professionals towards COVID-19 vaccines during the second peak period of the COVID-19 epidemic in Turkey, and to determine the mediating role of vaccine confidence in the effect of their attitudes towards COVID-19 vaccines on hesitancy. A hospital-based cross-sectional research design was used in the study. The population of the research consisted of the health workers of three different training and research hospitals operating in Istanbul. Convenience sampling method was preferred in the study. The data were collected by the researchers themselves using the online survey technique. A total of 440 questionnaires were evaluated. The data were analyzed with SPSS and AMOS package programs. The findings of the study revealed that nearly two-thirds of the participants had a positive attitude towards potential COVID-19 vaccines, partially having higher confidence and less hesitation. In addition, the empirical result of the study revealed that positive attitudes towards potential COVID-19 vaccines reduce vaccine hesitancy. In addition, it has been found that vaccine trust has a significant indirect effect and partially mediates the relationship between attitude towards potential COVID-19 vaccines and hesitancy. This research revealed that positive attitudes towards potential COVID-19 vaccines reduce vaccine hesitations through high vaccine confidence. Thus, increased positive attitudes towards potential COVID-19 vaccines and increased vaccine confidence were significantly associated with decreased vaccine hesitancy.