Under the innovation system integrated with production, teaching and researching, the evolution mechanism of knowledge theme becomes central point in academic fields. However, previous researches mostly focused on analyzing the tendency of academic achievements, didn’t bring the potential interaction between the production and researching into consideration. In this paper we will use the co-integration analysis and Granger causality test methods, which are prevalent in economics research, to study the evolution of specific knowledge theme – “Cloud computing”. Our main purpose is to reveal the evolution mechanism as well as general principle of popularity of one theme.

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