Although compositional gradients could be manufactured for the functionally graded coating that was showed to improve bonding strength between the coating and the substrate, the biological efficacy of the graded coatings remained unclear. In this study, a functionally graded nanophase hydroxyapatite/bioglass (n-HA/bioglass) coating was prepared on a titanium (Ti) substrate for evaluating peri-implant osteogenesis in a canine model. The bone apposition and osteointegration of n-HA/bioglass coating were investigated at the interface compared with plasma spraying HA (PS-HA) coating. The results showed that the coating degraded gradually over time but not as fast as PS-HA coating did, and that more active bone apposition appeared on the n-HA/bioglass coating. The in vivo study indicated that an early osteogenesis and osteointegration at the interface could be stimulated by the use of n-HA/bioglass coating in biological environment.

In this article, we compute cohomology groups of the semisimple Lie conformal algebra [Formula: see text] with coefficients in its irreducible modules for a finite-dimensional simple Lie algebra [Formula: see text].

The extending structures problem for strict Lie 2-algebras is studied. To provide the theoretical answer to this problem, this paper introduces the unified product of a given strict Lie 2-algebra g and 2-vector space V. The unified product includes some interesting products such as semi-direct product, crossed product, and bicrossed product. The paper focuses on crossed and bicrossed products, which give the answer to the extension problem and factorization problem, respectively.

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